Cobalt radiation with or without low-dose cisplatin for treatment of canine naso-sinus carcinomas

Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association
Marie-Eve NadeauSusan M LaRue

Abstract

The objective of this study was to determine if low-dose cisplatin could be added safely to radiation therapy for the treatment of naso-sinus carcinomas in dogs. Thirty-one dogs were evaluated; 18 of these dogs received cobalt radiation in combination with low-dose cisplatin while 13 dogs received radiation alone. No difference was observed for acute or late radiation effects. Cisplatin was administered at a dosage of 7.5 mg/m2 20 min prior to every other radiation treatment. An initial dose of 10 mg/m2 was intended but toxicity (primarily azotemia) was unacceptable. Cisplatin was administered as prescribed in 12 of 18 dogs. Cisplatin was discontinued in 2 dogs because of azotemia. In the other 4 dogs cisplatin was not administered as prescribed because the dogs were withdrawn from treatment due to disease progression or radiation effects. There was no long-term renal disease in patients who developed azotemia. The overall median survival was 433 days with 4 (12.9%) dogs still alive at the completion of the study.

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Citations

Jan 30, 2009·Journal of Veterinary Internal Medicine·K R HumeL E Williams
Oct 13, 2010·The Journal of Veterinary Medical Science·Takuya MaruoHiroo Madarame
Feb 18, 2016·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Lyndsay KubicekDavid Lurie
May 27, 2014·Natural Products and Bioprospecting·Elmar Breuer, Thomas Efferth
Dec 13, 2006·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Sibylle Kneissl, Alexander Probst
Jan 31, 2009·Veterinary and Comparative Oncology·K BarabasC Adin
Aug 30, 2008·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Margaret C McEnteeNathan L Dykes
Sep 29, 2007·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Catherine VaudauxBarbara Kaser-Hotz
Feb 5, 2013·The Journal of Small Animal Practice·A FujiwaraM Fujita
Jan 3, 2013·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Evan SonesZack Wright
Jul 6, 2018·The Journal of Small Animal Practice·M W Nolan, J M Dobson
Apr 14, 2020·Veterinary Ophthalmology·Friederike WolfCarla Rohrer Bley
Jan 22, 2014·Journal of the American Animal Hospital Association·Seth A GlasserRichard Joseph
Jul 19, 2013·Journal of the American Animal Hospital Association·Tracy GiegerKeijiro Shiomitsu

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