Cobalt(III)-Catalyzed C-H Amidation of 7-Azaindoles with Dioxazolones: Synthesis of 7-Azaindole Amidated Derivatives

The Journal of Organic Chemistry
Jun-Shu SunLin Dong

Abstract

An efficient cobalt-catalyzed C-H amidation of 7-azaindoles was developed by using dioxazolones as the amidating reagent. A wide scope of substituted 7-azaindoles, even N-vinly groups, is suitable for the reaction, generating 7-azaindoles derivatives with potential properties up to 91% yield under straightforward and strong applicable reaction conditions.

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