Cobalt(III)-Catalyzed Oxadiazole-Directed C-H Activation for the Synthesis of 1-Aminoisoquinolines

Organic Letters
Fan YangJin Zhu

Abstract

Aromatic heterocycles have been identified as effective directing groups (DGs) in C-H functionalization but can be retained as undesired bulky substituents in the final products. Herein, we report a Co(III)-catalyzed 1-aminoisoquinoline synthesis strategy based on oxadiazole-directed aromatic C-H coupling with alkynes and a subsequent redox-neutral C-N cyclization reaction. This labile N-O bond-based protocol has allowed the toleration of a broad range of functional groups.

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Citations

Jul 1, 2017·Dalton Transactions : an International Journal of Inorganic Chemistry·Paula G Chirila, Christopher J Whiteoak
Jul 24, 2018·Chemical Society Reviews·Carlo SambiagioMichael Schnürch
Jun 21, 2019·Chemical Communications : Chem Comm·Somaraju Yugandar, Hiroyuki Nakamura

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