Cocaine--stimulus generalization to MDA optical isomers: a reevaluation

Pharmacology, Biochemistry, and Behavior
Richard Young, Richard A Glennon

Abstract

It has already been demonstrated that the psychoactive agent 1-(3,4-methylenedioxyphenyl)-2-aminopropane (MDA) produces effects that are both hallucinogen-like and amphetamine or stimulant-like in animals. Hallucinogenic activity is associated primarily with the R(-)-isomer of MDA whereas stimulant activity is primarily associated with the S(+)-isomer. Because a previous report indicates that S(+)MDA fails to substitute for cocaine in rats trained to discriminate cocaine from vehicle, and because these findings are inconsistent with the purported stimulant nature of S(+)MDA, we reinvestigated the effect of both MDA isomers in rats. In this investigation, S(+)MDA doses of 1.25 and 1.5 mg/kg were found to produce > 80% cocaine-appropriate responding in rats trained to discriminate 8 mg/kg of cocaine from saline. However, consistent with a previous report, R(-)MDA resulted only in partial generalization. These new results support the hypothesis that the optical isomers of MDA produce distinguishable stimulus effects in rats and that S(+)MDA is the more stimulant isomer of MDA.

References

Dec 1, 1978·Neuropharmacology·G ShearmanH Lal
Jan 1, 1988·Psychopharmacology·R Oberlender, D E Nichols
Jan 1, 1986·Medicinal Research Reviews·R Young, R A Glennon
Mar 23, 1984·European Journal of Pharmacology·R A Glennon, R Young
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May 1, 1993·Pharmacology, Biochemistry, and Behavior·R Young, R A Glennon
Oct 1, 1992·Behavioural Pharmacology·J. BroadbentJ.H. Ricker

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Citations

Mar 20, 2002·Pharmacology, Biochemistry, and Behavior·Richard A Glennon, Richard Young
Aug 11, 2004·Pharmacology, Biochemistry, and Behavior·Nantaka KhoranaRichard A Glennon
Jun 24, 2000·Journal of the Experimental Analysis of Behavior·J O'DonnellK J Saunders

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