Cocaine abstinence alters nucleus accumbens firing dynamics during goal-directed behaviors for cocaine and sucrose.

The European Journal of Neuroscience
Courtney M Cameron, Regina M Carelli

Abstract

Distinct subsets of nucleus accumbens (NAc) neurons differentially encode goal-directed behaviors for natural vs. drug rewards [R. M. Carelli et al. (2000)The Journal of Neuroscience, 20, 4255-4266], and the encoding of cocaine-seeking is altered following cocaine abstinence [J. A. Hollander & R. M. Carelli (2007) The Journal of Neuroscience, 27, 3535-3539]. Here, electrophysiological recording procedures were used to determine if the selective encoding of natural vs. cocaine reward by NAc neurons is: (i) maintained when the natural reinforcer is a highly palatable sweet tastant and (ii) altered by cocaine abstinence. Rats (n = 14) were trained on a multiple schedule of sucrose reinforcement and cocaine self-administration (2-3 weeks) and NAc activity was recorded during the task before and after 30 days of cocaine abstinence. Of 130 cells recorded before abstinence, 82 (63%) displayed patterned discharges (increases or decreases in firing rate, termed phasic activity) relative to operant responding for sucrose or cocaine. As in previous reports, the majority of those cells displayed nonoverlapping patterns of activity during responding for sucrose vs. cocaine. Specifically, only 17 (21%) showed similar patterns of activity (i....Continue Reading

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Citations

Feb 22, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kyle K PitchersLique M Coolen
Jun 20, 2014·CNS Drugs·Shaun Yon-Seng Khoo, Robyn Mary Brown
Dec 18, 2013·Biological Psychiatry·Benjamin T Saunders, Patricia H Janak
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Sep 13, 2016·Neuropharmacology·Courtney M CameronRegina M Carelli
May 14, 2016·Journal of Neurophysiology·Andrea L Gutman, Sharif A Taha
Sep 29, 2020·Molecular Psychiatry·Ana-Clara BobadillaPeter W Kalivas
Oct 8, 2020·Nature Reviews. Neuroscience·Marco VenniroYavin Shaham
Jan 10, 2021·Journal of Neurochemistry·Rusty W NallAna-Clara Bobadilla
Feb 15, 2021·Neuropharmacology·Miriam WandresChristoph Körber

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