Abstract
Cocaine abuse in pregnancy has been evaluated through toxicological analysis of hair from 123 pathological new-borns admitted in an intensive care division. The new-borns were affected with malformations, low gestational age, low birth weight, respiratory distress. A control group of 39 healthy new-borns was also analysed. Hair samples (about 50 mg) were enzymatically digested and directly analysed by RIA. Samples positive to the preliminary screening were extracted by SPE columns and injected in GC/MS. Results obtained showed 3 positive samples (2.4%). All cocaine babies had low gestational age, low birth weight, two of them showed heart malformation, one kidney malformation and one genital malformation. None of the control new-born resulted positive for cocaine. These results show a worrying trend of cocaine diffusion in the Italian population.
References
Apr 1, 1992·The Journal of Infectious Diseases·J M DurandJ Soubeyrand
Jan 1, 1992·Life Sciences·R FormanG Koren
Nov 1, 1991·American Journal of Obstetrics and Gynecology·B L TaborM L Yonekura
Jan 1, 1991·The Journal of Pediatrics·S E LipshultzE J Orav
Nov 1, 1990·Journal of Analytical Toxicology·J E Meeker, P C Reynolds
Oct 1, 1990·The Journal of Pediatrics·A SalamyD Bull
Oct 1, 1990·The Journal of Pediatrics·D A FrankB Zuckerman
Sep 1, 1990·Forensic Science International : Synergy·I Morild, M Stajic
Jun 1, 1990·Teratology·W S Webster, P D Brown-Woodman
Dec 15, 1989·JAMA : the Journal of the American Medical Association·K GrahamM Greenwald
Jan 1, 1988·Neurotoxicology and Teratology·M W ChurchP K Gessner
Aug 1, 1988·The Journal of Pediatrics·T M DoberczakS R Kandall
Oct 1, 1987·The Journal of Pediatrics·A S Oro, S D Dixon
Jan 1, 1987·The Journal of Pediatrics·N BingolD S Gromisch
Feb 20, 1987·JAMA : the Journal of the American Medical Association·J R WoodsK E Clark
Sep 12, 1985·The New England Journal of Medicine·I J ChasnoffK A Burns
Jun 1, 1980·Journal of Pharmaceutical Sciences·M P MahalikD E Mann
Oct 1, 1994·The Journal of Pediatrics·S PotterP R Zelazo
Citations
Mar 18, 1999·Drug and Alcohol Dependence·S Strano-Rossi
Aug 8, 2001·Reproductive Toxicology·A AddisG Koren
Jan 24, 2002·Therapeutic Drug Monitoring·Gideon KorenTatiana Karaskov
Nov 29, 2007·Therapeutic Drug Monitoring·Jaime LozanoSimona Pichini