Cocaine addiction is associated with abnormal prefrontal function, increased striatal connectivity and sensitivity to monetary incentives, and decreased connectivity outside the human reward circuit

Addiction Biology
Lucía VaqueroJordi Riba

Abstract

Cocaine addiction has been associated with increased sensitivity of the human reward circuit to drug-related stimuli. However, the capacity of non-drug incentives to engage this network is poorly understood. Here, we characterized the functional sensitivity to monetary incentives and the structural integrity of the human reward circuit in abstinent cocaine-dependent (CD) patients and their matched controls. We assessed the BOLD response to monetary gains and losses in 30 CD patients and 30 healthy controls performing a lottery task in a magnetic resonance imaging scanner. We measured brain gray matter volume (GMV) using voxel-based morphometry and white matter microstructure using voxel-based fractional anisotropy (FA). Functional data showed that, after monetary incentives, CD patients exhibited higher activation in the ventral striatum than controls. Furthermore, we observed an inverted BOLD response pattern in the prefrontal cortex, with activity being highest after unexpected high gains and lowest after losses. Patients showed increased GMV in the caudate and the orbitofrontal cortex, increased white matter FA in the orbito-striatal pathway but decreased FA in antero-posterior association bundles. Abnormal activation in the...Continue Reading

References

Apr 9, 1999·Nature Neuroscience·J R Hollerman, W Schultz
Dec 20, 2000·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·G F Koob, M Le Moal
Mar 7, 2001·The American Journal of Psychiatry·L K JacobsenJ H Krystal
Jan 16, 2003·Physiology & Behavior·Vincent van Veen, Cameron S Carter
Aug 12, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Robert M BilderAnthony A Grace
Oct 16, 2004·Science·K Richard RidderinkhofSander Nieuwenhuis
Apr 30, 2005·Biological Psychiatry·Linda ChangThomas Ernst
Oct 28, 2005·Nature Neuroscience·George F Koob, Michel Le Moal
Oct 28, 2005·Nature Neuroscience·Barry J Everitt, Trevor W Robbins
Nov 15, 2006·The European Journal of Neuroscience·Thomas A StalnakerGeoffrey Schoenbaum
Feb 27, 2007·Psychiatry Research·F Gerard MoellerPonnada A Narayana
May 30, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yoshimoto SekineJean L Cadet
Nov 11, 2008·Annals of the New York Academy of Sciences·Minoru NaritaTsutomu Suzuki
May 13, 2009·Pharmacopsychiatry·D M DietzS J Russo
Aug 28, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·George F Koob, Nora D Volkow
Jul 28, 2010·PloS One·Scott D LaneFrederick Gerard Moeller
Jul 31, 2010·Science·Joshua W BuckholtzDavid H Zald
Jan 29, 2011·Annals of the New York Academy of Sciences·Daniel W HommerJodi M Gilman
Mar 16, 2011·Proceedings of the National Academy of Sciences of the United States of America·Nora D VolkowFrank Telang
Jan 1, 2009·BMJ Case Reports·D KondziellaP Arlien-Soeborg
Oct 4, 2011·Annual Review of Pharmacology and Toxicology·Nora D VolkowDardo Tomasi
Oct 21, 2011·Nature Reviews. Neuroscience·Rita Z Goldstein, Nora D Volkow
Jun 25, 2013·Drug and Alcohol Dependence·Robert HesterHugh Garavan
Jul 16, 2014·Neuropharmacology·Fred Nyberg
Oct 1, 2014·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Jeffrey J Stott, A David Redish

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Citations

Sep 6, 2017·Genes, Brain, and Behavior·A C W Smith, P J Kenny
Oct 9, 2018·Addiction Biology·Sheng ZhangChiang-Shan R Li
Apr 7, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·J Marín-LahozJ Kulisevsky
May 8, 2019·Addiction Biology·Caio V I MeloPaulo Jannuzzi Cunha
Jan 4, 2020·Brain Imaging and Behavior·Saul Martinez-HortaJaime Kulisevsky
Aug 12, 2020·Nature Communications·Sebastiano BariselliAlexxai V Kravitz
Feb 10, 2021·Pharmacology, Biochemistry, and Behavior·Michael L RohanSusan L Andersen

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