PMID: 1197578Oct 14, 1975Paper

Cocaine and amphetamine modification of cerebral energy metabolism in vivo

Psychopharmacologia
L J KingL Lao

Abstract

At the time of maximal behavioral stimulation after injection of amphetamine (5 mg/kg) in mice, elevation of cerebral cortical levels of malate in the citric acid cycle and of the amino acid, alanine, was observed, suggesting that this drug has widespread effects on energy metabolism. Cocaine (20 mg/kg), in contrast, produced elevation of brain glucose but not of citric acid cycle substrates or amino acids at the time of maximal hyperactivity. These observations are discussed in terms of the mechanisms of action of these two central nervous system stimulants.

References

May 1, 1975·British Journal of Pharmacology·E FriedmanJ Rotrosen
Dec 1, 1972·The British Journal of Addiction to Alcohol and Other Drugs·H O Collier
Jul 16, 1973·Brain Research·K J Rogers, S R Nahorski
Sep 1, 1973·Journal of Neurochemistry·S R Nahorski, K J Rogers
Feb 1, 1974·Journal of Neurochemistry·L J KingL Lao
Aug 1, 1959·Biochemical Pharmacology·B M BOLLARD, H McILWAIN

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Citations

May 1, 1978·Journal of the Neurological Sciences·M OishiF Gotoh
Mar 1, 1978·Acta Physiologica Scandinavica·L BerntmanB K Siesjö
Oct 1, 1984·The Journal of General Psychology·S H EvansF H Gage

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