Cocaine and food deprivation: effects on food-reinforced fixed-ratio performance in pigeons

Journal of the Experimental Analysis of Behavior
C E HughesMarc N Branch

Abstract

Key pecking by 6 pigeons was maintained by a fixed-ratio 30 schedule of food presentation while body weights were 80% of free-feeding weights. Acute administration of cocaine (0.3 to 13.0 mg/kg, i.m.) dose-dependently decreased response rates. Dose-effect curves were shifted to the right when 3 of the 6 pigeons were maintained at 70% of free-feeding weights and were shifted to the left when the other 3 pigeons were maintained at 90% of free-feeding weights. Then a dose of cocaine that initially decreased response rates by more than 95% of control rates was administered before each daily session. Comparable degrees of tolerance to these rate-decreasing effects developed in the two groups. The rate at which responding recovered was relatively rapid for pigeons in the 70% free-feeding-weight group and was slower for 2 of the 3 pigeons in the 90% free-feeding-weight group. When body weights were then increased from 70% to 80% or were decreased from 90% to 80% of free-feeding weight, performance was disrupted initially only for pigeons whose weight went from 70% to 80% of free feeding. In the present experiment the degree of deprivation may have indirectly influenced the degree of tolerance that developed to cocaine's response rate-...Continue Reading

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Citations

Jul 30, 2005·Journal of the Experimental Analysis of Behavior·Christine E HughesLinda A Dykstra
May 26, 1998·Journal of the Experimental Analysis of Behavior·A L OdumD W Schaal
Sep 11, 2013·Journal of the Experimental Analysis of Behavior·Vanessa Minervini, Marc N Branch
Mar 17, 2015·Pharmacology, Biochemistry, and Behavior·Christopher A Krebs, Karen G Anderson

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