Cocaine and metabolites in human graying hair: pigmentary relationship

Journal of Toxicology. Clinical Toxicology
R W ReidJ W Crayton

Abstract

To assess differences in the binding of cocaine, cocaethylene, and benzoylecgonine among pigmented and senile white hairs of the graying human cocaine abuser. A sheath of graying hair in the region around the apex of the head was gathered between the thumb and index finger then cut and removed about 2 mm proximal to the scalp. The graying hair was divided into pigmented and senile white of equal weights and lengths and then analyzed by gas chromatography/mass spectrometry chemical ionization. Twenty-nine such pairs were analyzed. Male cocaine abusers, ages 33-55 years hospitalized for substance abuse. Informed consent was obtained and confidentiality assured. Concentrations of cocaine, cocaethylene and benzoylecgonine in ng were assessed for each of 29 paired hair samples by gas chromatography/mass spectrometry chemical ionization. There were statistically significant differences between pigmented and senile white sections of paired samples. Cocaine (ng/mg hair, mean +/- SD) was 31.5 +/- 30.2 for pigmented hair vs 14.9 +/- 19.8 for senile white portions; (p < 0.0001). Cocaethylene (ng/mg hair, mean +/- SD) 3.22 +/- 5.0 (pigmented) vs 0.52 +/- 0.88 (senile white); (p < 0.0016). Benzoylecgonine (ng/mg hair, mean +/- SD) 5.1 +/- 5...Continue Reading

References

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Citations

Jan 2, 2008·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·John Curtis, Michael Greenberg
Jan 20, 2009·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Vivian KulagaGideon Koren
Feb 9, 2016·Alcoholism, Clinical and Experimental Research·Jan Toralf FosenGudrun Høiseth
Jun 1, 2007·Forensic Science, Medicine, and Pathology·R KronstrandN Dizdar
Sep 4, 2015·Clinical Drug Investigation·Jessica K RobertsCatherine M T Sherwin
Sep 17, 2004·Drug and Alcohol Review·Kate DolanJo Kimber
Nov 26, 1999·Journal of Chromatography. B, Biomedical Sciences and Applications·Y Nakahara
Feb 26, 2000·Forensic Science International : Synergy·T Mieczkowski, R Newel

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