PMID: 2096404Jan 1, 1990Paper

Cocaine-base smoking in rhesus monkeys: reinforcing and physiological effects

Psychopharmacology
M E CarrollD A Sadoff

Abstract

Four rhesus monkeys were trained to smoke cocaine-base under a progressive ratio (PR) schedule, with ten smoking trials available each day. Unit dose was varied from 0.25 to 3 mg/kg, and lidocaine (2 mg/kg) was substituted for cocaine. Number of responses and break-point on the PR schedule increased with dose while the number of smoke deliveries increased only slightly. Maximum daily smoke deliveries ranged from six to nine across monkeys. When lidocaine (2 mg/kg) was substituted for cocaine-base, responding decreased to approximately half of that maintained by cocaine, and when cocaine was reinstated, higher response rates returned. Cardiovascular changes associated with cocaine smoking were monitored with an indwelling radio transmitter. There was an initial decrease in heart rate (30 s) followed by a rapid rise and decline by the end of the 15-min trials. Blood pressure increased rapidly after trial onset and returned to pretrial baseline by 15 min. Over the eight trials completed during a session, heart rate and blood pressure steadily increased over presession base-lines during the first four trials, but there was then a decline suggesting acute tolerance development. Observations of the monkeys after each trial revealed d...Continue Reading

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Citations

May 1, 1995·Psychopharmacology·S D ComerM E Carroll
Jun 1, 1996·Psychopharmacology·A J Mattox, M E Carroll
Aug 29, 2006·Psychopharmacology·Jennifer L Newman, Marilyn E Carroll
Mar 1, 1994·Pharmacology, Biochemistry, and Behavior·D K HatsukamiK Hanson
Jun 1, 1996·Pharmacology, Biochemistry, and Behavior·S R Tella
Jun 1, 1995·Drug and Alcohol Dependence·A H LichtmanB R Martin
Nov 7, 1996·European Journal of Pharmacology·E AmbrosioG I Elmer
Feb 14, 2002·Pharmacology, Biochemistry, and Behavior·A R CaggiulaA F Sved
Feb 26, 1998·Pharmacology, Biochemistry, and Behavior·S R Tella, S R Goldberg
Feb 4, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Gregory T CollinsMei-Chuan Ko
May 11, 1999·Alcoholism, Clinical and Experimental Research·K R BruceR O Pihl
Jun 15, 2007·Pharmacology, Biochemistry, and Behavior·Jennifer L NewmanMarilyn E Carroll
Nov 6, 2007·Biochemical Pharmacology·William E FantegrossiChad J Reissig
Jan 18, 2006·Neurotoxicology and Teratology·Fang HeMichael S Lidow
Dec 3, 2016·Journal of Psychopharmacology·Clinton E Canal, Kevin S Murnane
Jan 1, 1996·Addiction Biology·C W Schindler

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