Cocaine dependence and stroke: pathogenesis and management

Current Neurovascular Research
Antonio SiniscalchiLuca Gallelli

Abstract

Cocaine abuse remains a devastating medical problem for our society. Current concepts suggest that both hemorrhagic and ischemic stroke, particularly in young people, can result as a consequence of cocaine exposure. We provide an analysis of mechanisms of injury and a discussion of the pharmacological management of stroke following cocaine use. Preclinical research suggests that the cause of cocaine-mediated stroke is multifactorial and involves vasospasm, changes in cerebral vasculature, and platelet aggregation. We suggest that drugs able to induce vasospastic, thrombogenic, or neurotoxic effects of cocaine could be suitable as therapeutic agents. In contrast caution should be exerted when using anti-platelet and thrombolytic agents in cocaine users with stroke.

Citations

Jun 25, 2015·Neurotoxicity Research·Renato B PereiraPatrícia Valentão
Apr 24, 2016·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·C TanislavC Enzinger
Apr 30, 2015·Neurology Research International·Nikhil AggarwalVassilios Vassiliou
Sep 15, 2016·The American Journal of Emergency Medicine·Antonio SiniscalchiLuca Gallelli
Sep 30, 2020·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Muhammad Zeeshan MemonDileep R Yavagal

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