PMID: 9537681Apr 16, 1998Paper

Cocaine discrimination: relationship to local anesthetics and monoamine uptake inhibitors in C57BL/6 mice

Psychopharmacology
L D MiddaughB Adinoff

Abstract

Although the discriminative properties of cocaine have been examined extensively in rats, and to a lesser extent in other species, there are currently no reports on cocaine discrimination by mice. In one of our experiments, C57BL/6 (C57) mice acquired cocaine discrimination (10 mg/kg training dose) and exhibited dose responsive generalization to lower doses of the drug, which was similar to previous reports using rats. In addition, mazindol, a general monoamine uptake inhibitor similar to cocaine, and nomifensine, which is relatively specific for the dopamine transporter, substituted completely for cocaine, as described for rats. In contrast, there was little substitution evidenced by monoamine uptake inhibitors relatively specific for the norepinephrine transporter (nisoxetine) or for the serotonin transporter (fluoxetine), or by the local anesthetics procaine or lidocaine. In our second experiment, neither cocaine nor mazindol substituted for procaine in animals trained to discriminate the local anesthetic (100 mg/kg) although lidocaine substituted completely for the procaine cue. These experiments emphasize the importance of the dopamine transporter in mediating the discriminative stimulus effects of cocaine in C57 mice. The...Continue Reading

Citations

May 24, 2001·Progress in Neuro-psychopharmacology & Biological Psychiatry·S R Tella, S R Goldberg
Sep 6, 2003·Drug and Alcohol Dependence·Bryon AdinoffMark J Williams
Dec 17, 2010·Behavioural Pharmacology·Robin W McGovernWilliam C Griffin
Jun 30, 2009·Psychiatry Research·Bryon AdinoffMark J Williams
Jul 12, 2005·Pharmacology, Biochemistry, and Behavior·J C WinterJ B Richards
Feb 13, 2014·The Journal of Pharmacology and Experimental Therapeutics·Takato HiranitaJonathan L Katz
Apr 1, 1998·Addiction Biology·B AdinoffC H Kellner

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