Cocaine, dopamine and the endogenous opioid system

Journal of Addictive Diseases
M J Kreek

Abstract

Cocaine addiction and opiate addiction are both major health problems in the United States today. Prospective studies from our Laboratory, which were able to detect the advent of the HIV-1 epidemic in parenteral drug abusers in New York City beginning around 1978, also showed that, from the beginning of the AIDS epidemic, cocaine abuse was a very important co-factor significantly increasing the risk for developing cocaine dependency. Fundamental studies from many laboratories including our own have shown that cocaine has profound effects on dopaminergic function, primarily from its well-established primary action of blocking the reuptake of dopamine from the synaptic cleft, an action of cocaine directed at the specific dopamine transporter. It has also been well-established by others that cocaine similarly blocks the reuptake of serotonin and norepinephrine. However, recent studies from our laboratory have shown that chronic cocaine administration profoundly disrupts the endogenous opioid system. Extensive studies have been conducted using an animal model which we have developed in our laboratory, the "binge" pattern cocaine administration model. Findings from these studies have led us to recognize the profound disruption of bo...Continue Reading

Citations

Mar 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Kyoung-Shim KimPyung-Lim Han
Jan 4, 2003·Substance Abuse : Official Publication of the Association for Medical Education and Research in Substance Abuse·Gopakumar P. Panikkar
Jun 27, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·María-Julia García-FusterHuda Akil
Apr 3, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Covadonga PañedaAmanda J Roberts
Mar 30, 2011·Pharmacological Reviews·Christopher W CunninghamThomas E Prisinzano
Feb 10, 2004·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Krzysztof M Kuczkowski
Apr 7, 2006·Journal of Addictive Diseases·Einat PelesMiriam Adelson
Jun 14, 2005·Brain Research. Molecular Brain Research·Alexis BaileyMary Jeanne Kreek
Nov 28, 2007·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Jeanne E BellIain C Anthony
Jan 12, 2000·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·A Margolin, S K Avants
Sep 17, 2011·Pharmacogenomics·Shinya Kasai, Kazutaka Ikeda
Jul 13, 2011·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Francesco LeriMary Jeanne Kreek
Nov 8, 2008·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Francesco LeriMary Jeanne Kreek
Oct 25, 2006·Neuropharmacology·B J HoplightJ F Neumaier
Feb 3, 2005·Acta Obstetricia Et Gynecologica Scandinavica·Krzysztof M Kuczkowski
Jan 20, 2006·The European Journal of Neuroscience·Ivan GoussakovVadim Y Bolshakov
Jun 11, 2008·Alcoholism, Clinical and Experimental Research·Francesca M FilbeyKent E Hutchison
Dec 12, 2012·Anaesthesia·G T C Wong, M G Irwin
Nov 16, 2004·Psychiatry Research·Marc L CopersinoRobert Cancro
Jul 1, 1999·The Psychiatric Clinics of North America·M A Enoch, D Goldman
Jul 29, 2008·Biological Psychiatry·Sarah L TeegardenTracy L Bale
Apr 21, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Edward F DominoJon-Kar Zubieta
May 10, 2011·Physiology & Behavior·Erin N Umberg, Emmanuel N Pothos
Jan 15, 2017·European Journal of Pharmacology·Anna WzgardaBeata J Stanisz
Nov 1, 2002·International Anesthesiology Clinics·Joshua A Bloomstone
Nov 30, 2005·Psychiatric Genetics·Riju RayWade H Berrettini
Feb 6, 2004·The Journal of Pharmacology and Experimental Therapeutics·Genya GekkerPhillip K Peterson
Jul 28, 2005·The Journal of Biological Chemistry·Ying ZhangWolfgang Sadée
Sep 16, 2003·Obstetrical & Gynecological Survey·Krzysztof M Kuczkowski
Jun 7, 2019·CNS Spectrums·Jon E Grant, Samuel R Chamberlain
Nov 25, 2005·Bulletin of Experimental Biology and Medicine·N N KudryavtsevaJ M Van Ree
Dec 19, 2007·Anaesthesia and Intensive Care·J LudlowB Orr

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