Cocaine exposure impairs multilineage hematopoiesis of human hematopoietic progenitor cells mediated by the sigma-1 receptor [corrected

Scientific Reports
Christopher C NixonDimitrios N Vatakis

Abstract

Prenatal exposure to cocaine is a significant source of fetal and neonatal developmental defects. While cocaine associated neurological and cardiac pathologies are well-documented, it is apparent that cocaine use has far more diverse physiological effects. It is known that in some cell types, the sigma-1 receptor mediates many of cocaine's cellular effects. Here we present a novel and concise investigation into the mechanism that underlies cocaine associated hematopoietic pathology. Indeed, this is the first examination of the effects of cocaine on hematopoiesis. We show that cocaine impairs multilineage hematopoiesis from human progenitors from multiple donors and tissue types. We go on to present the first demonstration of the expression of the sigma-1 receptor in human CD34 + human hematopoietic stem/progenitor cells. Furthermore, we demonstrate that these cocaine-induced hematopoietic defects can be reversed through sigma-1 receptor blockade.

References

Jan 1, 1996·Pharmacology, Biochemistry, and Behavior·B M BayerX Z Ding
Apr 21, 1997·The Journal of Experimental Medicine·M TianL Yu
Jun 4, 1998·Journal of Neuroimmunology·T Pellegrino, B M Bayer
Jul 17, 1998·Advances in Experimental Medicine and Biology·D F KumpJ A Rosecrans
Jul 3, 2003·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Jim Edward WeberJudd E Hollander
Sep 7, 2005·Archives of Pediatrics & Adolescent Medicine·Charles R BauerJoel Verter
Oct 6, 2005·Journal of Leukocyte Biology·Michael D RothGayle Cocita Baldwin
Jan 16, 2009·Therapeutic Advances in Cardiovascular Disease·Kurt D Meyer, Lubo Zhang
Jul 22, 2009·Pharmacology & Therapeutics·Tangui Maurice, Tsung-Ping Su
Jan 19, 2010·Proceedings of the National Academy of Sciences of the United States of America·Helene BenvenisteNora D Volkow
Oct 12, 2010·Life Sciences·Vadivel Ganapathy
Oct 20, 2010·Proceedings of the National Academy of Sciences of the United States of America·Gemma NavarroRafael Franco
Nov 6, 2010·Current Topics in Medicinal Chemistry·Sanju NarayananChristopher R McCurdy
Dec 20, 2012·PloS One·Chinmay K MantriChandravanu C V Dash
Feb 27, 2013·Pediatrics·Marylou BehnkeUNKNOWN Committee on Fetus and Newborn
Jul 3, 2013·Journal of Leukocyte Biology·Sohn G KimDimitrios N Vatakis
Jun 1, 1998·Annals of the New York Academy of Sciences·Gale A Richardson

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Citations

Aug 29, 2018·Molecular Neurobiology·Susmita SilShilpa Buch
Oct 12, 2018·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Omar Vélez LópezLoyda M Meléndez

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Methods Mentioned

BETA
flow cytometry

Software Mentioned

Graphpad Prism

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