Cocaine impairs serial-feature negative learning and blood-brain barrier integrity

Pharmacology, Biochemistry, and Behavior
Terry L DavidsonAnthony L Riley

Abstract

Previous research has shown that diets high in fat and sugar [a.k.a., Western diets (WD)] can impair performance of rats on hippocampal-dependent learning and memory problems, an effect that is accompanied by selective increases in hippocampal blood brain barrier (BBB) permeability. Based on these types of findings, it has been proposed that overeating of a WD (and its resulting obesity) may be, in part, a consequence of impairments in these anatomical substrates and cognitive processes. Given that drug use (and addiction) represents another behavioral excess, the present experiments assessed if similar outcomes might occur with drug exposure by evaluating the effects of cocaine administration on hippocampal-dependent memory and on the integrity of the BBB. Experiment 1 of the present series of studies found that systemic cocaine administration in rats also appears to have disruptive effects on the same hippocampal-dependent learning and memory mechanism that has been proposed to underlie the inhibition of food intake. Experiment 2 demonstrated that the same regimen of cocaine exposure that produced disruptions in learning and memory in Experiment 1 also produced increased BBB permeability in the hippocampus, but not in the str...Continue Reading

References

Jan 1, 1992·Psychopharmacology·A W LogueS Schachter
Jan 1, 1988·Annual Review of Neuroscience·R A Rescorla
Jun 1, 1967·Psychological Bulletin·R J Douglas
Nov 1, 1968·Psychological Bulletin·D P Kimble
Jan 1, 1983·Neuroscience and Biobehavioral Reviews·J A Gray, N McNaughton
Apr 29, 1999·Clinical Immunology : the Official Journal of the Clinical Immunology Society·X GanM Fiala
May 5, 1999·Hippocampus·P C HollandM Gallagher
Feb 13, 2001·Behavioural Brain Research·K H ChanT L Davidson
Jan 16, 2002·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·J David JentschJane R Taylor
Dec 9, 2003·Behavioural Brain Research·Tracie A PaineMary C Olmstead
Apr 14, 2004·The European Journal of Neuroscience·Geoffrey SchoenbaumBarry Setlow
Jul 1, 2004·Neuroscience and Biobehavioral Reviews·T L Davidson, Leonard E Jarrard
Nov 24, 2004·Neuroscience and Biobehavioral Reviews·Mark E Bouton, Erik W Moody
Nov 16, 2006·Annals of the New York Academy of Sciences·N Del OlmoE Ambrosio
Apr 8, 2009·Cell and Tissue Research·J B Dietrich
Aug 1, 2009·Journal of Applied Physiology·Sirajedin S NatahJeff F Dunn
Apr 24, 2010·Journal of Alzheimer's Disease : JAD·Scott E KanoskiTerry L Davidson
Dec 2, 2010·Physiology & Behavior·Anthony L Riley
Mar 5, 2011·Biological Psychiatry·Jazmin CamchongKelvin O Lim
Jan 31, 2012·Neuroscience and Biobehavioral Reviews·Amy L Milton, Barry J Everitt
Jul 4, 2012·Frontiers in Pharmacology·Sharanya M KousikPaul M Carvey
Sep 29, 2012·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·N D VolkowR D Baler
Jan 22, 2013·Trends in Neurosciences·Alexander W Johnson
Jul 28, 2013·Neurobiology of Learning and Memory·T L DavidsonS E Swithers
Feb 22, 2014·Psychopharmacology·Stéphanie PuigFlorence Noble
Mar 19, 2014·Physiology & Behavior·Ashley A Martin, Terry L Davidson
Apr 23, 2014·British Journal of Pharmacology·Christina J PerryAndrew J Lawrence
May 23, 2014·Frontiers in Aging Neuroscience·Ted M Hsu, Scott E Kanoski
Sep 30, 2014·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·I García-GarcíaJ Neumann
Oct 4, 2014·Frontiers in Psychology·Kenneth BlumMark S Gold

❮ Previous
Next ❯

Citations

Feb 7, 2020·Current Pharmaceutical Design·Matthew M ClasenTerry L Davidson
Sep 14, 2018·Frontiers in Behavioral Neuroscience·Bruno Lobao-SoaresAna Carolina Luchiari

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.

Blood Brain Barrier Regulation in Health & Disease

The blood brain barrier is essential in regulating the movement of molecules and substances in and out of the brain. Disruption to the blood brain barrier and changes in permeability allow pathogens and inflammatory molecules to cross the barrier and may play a part in the pathogenesis of neurodegenerative disorders. Here is the latest research in this field.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.

Related Papers

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
Carrie R Ferrario, Terry E Robinson
© 2022 Meta ULC. All rights reserved