PMID: 2508148Jan 1, 1989Paper

Cocaine produces low dose locomotor depressant effects in mice

Psychopharmacology
F R George

Abstract

Cocaine produces several behavioral effects, most notably locomotor stimulation. Biochemically, cocaine is known to inhibit reuptake at the three monoamine transporter sites, and may have highest affinity at the serotonin transporter. Serotonin augmentation has been associated with decreases in behavioral activity, but cocaine has not been reported to produce behavioral depressant effects except at high doses which cause stereotypy and disruption of behavior. This study examined the effects of relatively low doses of cocaine, in the range of 0.1-10 mg/kg, on locomotor activity in C57BL/6J and DBA/2J mice. A biphasic dose-response curve was seen for both strains. At the lowest doses, activity was depressed. As the dose of cocaine increased, activity returned to baseline, and at the highest doses, increases in locomotor activity were found. DBA/2J mice were depressed at a lower dose of cocaine than were C57BL/6J mice; however, C57BL/6J mice showed locomotor depression over a broader range of doses. Activity was maximally depressed at 0.1 mg/kg for DBA/2J mice, and maximally depressed at 0.3 mg/kg for C57BL/6J mice. Thus, low doses of cocaine are shown to produce significant decreases in locomotor activity in two strains of mice. ...Continue Reading

References

Apr 29, 1977·Psychopharmacology·L ShusterA Bates
Oct 1, 1986·Pharmacology, Biochemistry, and Behavior·F L SmithW H Lyness
Jan 1, 1988·Pharmacology, Biochemistry, and Behavior·J A RuthA C Collins
Mar 1, 1986·Pharmacology, Biochemistry, and Behavior·J B Lucot, L S Seiden
Aug 1, 1967·Life Sciences·K J BlackburnR J Merrills
Sep 1, 1969·European Journal of Pharmacology·S B Ross, A L Renyi
Jan 1, 1982·Progress in Neuro-psychopharmacology & Biological Psychiatry·J Hyttel

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Citations

Aug 1, 1995·Molecular Neurobiology·M G Hadfield
Dec 1, 1992·Physiology & Behavior·I González-Burgos, L Cuevas-Alvarez
Oct 1, 1990·Pharmacology, Biochemistry, and Behavior·J M Witkin, S R Goldberg
Dec 1, 1990·Pharmacology, Biochemistry, and Behavior·F R George
Aug 1, 1991·Pharmacology, Biochemistry, and Behavior·F van Haaren, M E Meyer
Apr 1, 1991·Pharmacology, Biochemistry, and Behavior·F R George
Apr 1, 1991·Pharmacology, Biochemistry, and Behavior·F R GeorgeS R Goldberg
Oct 1, 1992·Pharmacology, Biochemistry, and Behavior·M G Hadfield, C Milio
Mar 1, 1992·Pharmacology, Biochemistry, and Behavior·N A DarmaniR A Glennon
Nov 1, 1992·Pharmacology, Biochemistry, and Behavior·E S OnaiviG H Loew
Feb 1, 1995·Pharmacology, Biochemistry, and Behavior·B K Tolliver, J M Carney
May 1, 1994·Pharmacology, Biochemistry, and Behavior·B K Tolliver, J M Carney
Mar 1, 1996·Pharmacology, Biochemistry, and Behavior·G I ElmerR B Rothman
May 1, 1993·Progress in Neuro-psychopharmacology & Biological Psychiatry·F R George
Mar 25, 1998·Pharmacology, Biochemistry, and Behavior·M N CookB C Jones
Jun 19, 1998·Pharmacology, Biochemistry, and Behavior·S D SchlussmanM J Kreek
Feb 9, 2010·Pharmacology, Biochemistry, and Behavior·Scott E BowenSusan Irtenkauf
Feb 24, 2007·Progress in Neurobiology·Christian P MüllerMaria A De Souza Silva
Oct 2, 2012·Drug and Alcohol Dependence·Xiaoyun Y ShenFrank M Orson
Sep 27, 2012·Pharmacology, Biochemistry, and Behavior·Rana A K SinghFrank M Orson
Jun 5, 2020·Psychopharmacology·Junchao TongStephen J Kish

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