Cocaine self-administration punished by intravenous histamine in adolescent and adult rats

Behavioural Pharmacology
Nathan A Holtz, Marilyn E Carroll

Abstract

Adolescence is a transitional phase marked by a heightened vulnerability to substances of abuse. It has been hypothesized that both increased sensitivity to reward and decreased sensitivity to aversive events may drive drug-use liability during this phase. To investigate possible age-related differences in sensitivity to the aversive consequences of drug use, adolescent and adult rats were compared on self-administration of cocaine before, during, and after a 10-day period in which an aversive agent, histamine, was added to the cocaine solution. Adult and adolescent female rats were trained to self-administer intravenous cocaine (0.4 mg/kg/infusion) over 10 sessions (2 h/session; 2 sessions/day). Histamine (4 mg/kg/infusion) was then added directly into the cocaine solution for the next 10 sessions. Finally, the cocaine/histamine solution was replaced with a cocaine-only solution, and rats continued to self-administer cocaine (0.4 mg/kg) for 20 sessions. Compared with adolescent rats, adult rats showed a greater decrease in cocaine self-administration when it was punished with intravenous histamine compared with their baseline cocaine self-administration rates. These results suggest that differences in the sensitivity to negati...Continue Reading

References

Apr 21, 1998·Biological Psychiatry·E F McCance-KatzP Jatlow
Sep 6, 2002·Physiology & Behavior·Bonnie J VastolaLinda P Spear
Jun 5, 2003·The American Journal of Psychiatry·R Andrew ChambersMarc N Potenza
Jun 14, 2003·Fundamental & Clinical Pharmacology·M Strolin Benedetti, E L Baltes
Jul 15, 2004·Annals of the New York Academy of Sciences·Carrie E Wilmouth, Linda P Spear
Jun 24, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Kyle J FrantzLoren H Parsons
Jul 4, 2006·Pharmacology, Biochemistry, and Behavior·Nicole L Schramm-SapytaCynthia M Kuhn
Jan 11, 2007·Psychopharmacology·Nicole L Schramm-SapytaCynthia M Kuhn
May 16, 2008·Pharmacology, Biochemistry, and Behavior·Erin Cummins, Francesco Leri
Jun 24, 2008·Pharmacology, Biochemistry, and Behavior·Oscar V TorresLaura E O'Dell
Aug 12, 2008·Behavioural Pharmacology·Marilyn E CarrollNancy K Dess
Sep 22, 2009·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Courtney Vetter-O'HagenLinda Spear
Dec 3, 2009·Psychopharmacology·Justin J Anker, Marilyn E Carroll
Mar 13, 2010·Current Opinion in Psychiatry·Kimberly Nixon, Justin A McClain
Apr 27, 2010·International Journal of Dermatology·Elke WeisshaarWolfgang U Eckart
Jul 14, 2010·Clinics in Dermatology·Stephanie W LiuNeil Alan Fenske
Sep 24, 2010·Alcoholism, Clinical and Experimental Research·Rachel I AndersonLinda P Spear
Dec 2, 2010·Physiology & Behavior·Anthony L Riley
May 28, 2011·Alcoholism, Clinical and Experimental Research·Charlotte H JørgensenHanne Tønnesen
Oct 1, 2011·Psychopharmacology·William L WoolvertonLeonard Green
Feb 7, 2012·Drug and Alcohol Dependence·Justin J AnkerMarilyn E Carroll
May 16, 2012·Developmental Psychobiology·Zachary E HurwitzAnthony L Riley
Aug 6, 2013·Addiction Biology·Amanda M Barkley-LevensonJohn C Crabbe

❮ Previous
Next ❯

Citations

Feb 24, 2016·Frontiers in Psychiatry·Marilyn E Carroll, John R Smethells
Feb 28, 2018·Journal of the Experimental Analysis of Behavior·Paulo César Morales MayerJonathan L Katz
Jun 22, 2018·Journal of the Experimental Analysis of Behavior·Vikki J BlandChristopher A Podlesnik
Feb 18, 2018·International Journal of Obesity : Journal of the International Association for the Study of Obesity·L J ZallarL Leggio
Feb 2, 2020·Psychopharmacology·C Austin ZamarripaKevin B Freeman
Mar 17, 2020·Cellular and Molecular Life Sciences : CMLS·Brooke N Bender, Mary M Torregrossa
Nov 24, 2020·Psychopharmacology·Sean C Monroe, Anna K Radke
May 4, 2021·Drug and Alcohol Dependence·Natalie E ZlebnikMarilyn E Carroll
Jan 26, 2021·Behavioural Pharmacology·Vanessa MinerviniCharles P France
Jun 10, 2020·Cold Spring Harbor Perspectives in Medicine·Louk J M J Vanderschuren, Serge H Ahmed
Aug 26, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Audrey DurandSerge H Ahmed
May 6, 2019·Neuroscience Letters·Kara Adams, Tom Byrne

❮ Previous
Next ❯

Software Mentioned

Med
GB Stat
PC
GraphPad

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.