Cocaine unbalances endothelial tissue factor and tissue factor pathway inhibitor expression

Journal of Molecular and Cellular Cardiology
Jan SteffelFelix C Tanner

Abstract

Cocaine consumption can lead to myocardial infarction. Tissue factor (TF) has been implicated in acute coronary syndromes, and the balance of TF and tissue factor pathway inhibitor (TFPI) determines initiation of thrombus formation. This study was designed to investigate the effect of cocaine on endothelial TF and TFPI expression. Cocaine (10(-8)-10(-5) mol/l) increased thrombin-induced TF expression by 24% at 10(-7) mol/l (P < 0.001) without affecting basal TF expression. In contrast, cocaine reduced endothelial TFPI expression by 47% at 10(-7) mol/l (P < 0.01). Moreover, thrombin impaired endothelial TFPI expression, and cocaine (10(-8) mol/l) further reduced TFPI expression by 33% as compared to thrombin (P < 0.02). These effects occur at cocaine concentrations usually present in plasma of consumers. Given the importance of TF in the pathogenesis of acute coronary syndromes, TF induction in conjunction with TFPI suppression may be relevant for the increased frequency of myocardial infarction observed in cocaine consumers.

Citations

May 24, 2014·Journal of Endocrinological Investigation·L ManettiA Ambrogio
Jan 9, 2014·Heart Failure Reviews·Lucas LiaudetPal Pacher
Nov 19, 2008·Journal of Molecular and Cellular Cardiology·Erik W HolyFelix C Tanner
Nov 14, 2013·International Journal of Vascular Medicine·Ahmed Al-MotarrebAyman El-Menyar
Sep 5, 2006·Biochemical and Biophysical Research Communications·Jan SteffelFelix C Tanner
Mar 18, 2017·Journal of Cardiovascular Medicine·Giovanni P TalaricoRoberto Patrizi
Nov 22, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Barbara E StähliFelix C Tanner
Nov 1, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·A BreitensteinF C Tanner
Dec 14, 2011·Circulation·Waleed M AliJassim Al Suwaidi
Jan 23, 2016·Anesthesia and Analgesia·José A AguirreMichael Zaugg
Jun 4, 2020·Heart Failure Reviews·Emilia DugoGiovanni Donato Aquaro

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