Cocaine use as an independent predictor of seizures after aneurysmal subarachnoid hemorrhage

Journal of Neurosurgery
Tiffany R ChangNeeraj S Naval

Abstract

Seizures are relatively common after aneurysmal subarachnoid hemorrhage (aSAH). Seizure prophylaxis is controversial and is often based on risk stratification; middle cerebral artery (MCA) aneurysms, associated intracerebral hemorrhage (ICH), poor neurological grade, increased clot thickness, and cerebral infarction are considered highest risk for seizures. The purpose of this study was to evaluate the impact of recent cocaine use on seizure incidence following aSAH. Prospectively collected data from aSAH patients admitted to 2 institutional neuroscience critical care units between 1991 and 2009 were reviewed. The authors analyzed factors that potentially affected the incidence of seizures, including patient demographic characteristics, poor clinical grade (Hunt and Hess Grade IV or V), medical comorbidities, associated ICH, intraventricular hemorrhage (IVH), hydrocephalus, aneurysm location, surgical clipping and cocaine use. They further studied the impact of these factors on "early" and "late" seizures (defined, respectively, as occurring before and after clipping/coiling). Of 1134 aSAH patients studied, 182 (16%) had seizures; 81 patients (7.1%) had early and 127 (11.2%) late seizures, with 26 having both. The seizure rate ...Continue Reading

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Citations

Nov 29, 2016·World Neurosurgery·Rouzbeh Motiei-LangroudiChristoph J Griessenauer
Aug 28, 2020·Journal of Neurology·Marvin Darkwah OppongRamazan Jabbarli
May 3, 2018·Bulletin of Emergency & Trauma·Abdolkarim RahmanianSoheil Motamed
Dec 29, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Garima SharmaHyoung-Chun Kim

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