Coccidioidomycosis in infants: A retrospective case series

Pediatric Pulmonology
Jessica M LeeMary Anne Tablizo

Abstract

In contrast to adults, coccidioidomycosis is a rare disease in infants and the mechanisms of disease acquisition are not well described in infants. The purpose of this study was to describe the clinical presentation, treatment, and outcome of pulmonary coccidioidomycosis in infants in an endemic area. We performed a retrospective observational study of all patients less than 12 months of age admitted to a tertiary free standing children's hospital from 2003-2012 diagnosed with coccidioidomycosis. Thirteen infants were hospitalized during the study period. The majority of the patients presented with upper and/or lower respiratory tract infection. The most common presenting symptoms included fever (77%), cough (61%), and respiratory distress (38%). Disseminated disease, included pericardial effusion, neck abscess, and lesions in the cerebellum, basal ganglia and left temporoparietal skull. Fluconazole was the initial, antifungal agent used. Amphotericin B was reserved for significant lung disease and disseminated cases. Failed response to fluconazole and amphotericin B were treated with a combination of voriconazole and caspofungin. Average length of treatment was 4 years. All patients survived to hospital discharge. The majority...Continue Reading

References

Apr 20, 1995·The New England Journal of Medicine·D A Stevens
Aug 15, 1993·American Journal of Ophthalmology·J L Stone, R E Kalina
Apr 19, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J N GalgianiP L Williams
Dec 12, 2001·Seminars in Respiratory Infections·B S Feldman, L S Snyder
May 5, 2005·The Journal of Infectious Diseases·Benjamin J ParkRana A Hajjeh
Nov 17, 2006·Journal of Clinical Microbiology·Michael A SaubolleDen Sussland
Jun 26, 2012·The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases·Rahim RaoofiYadollah Pournia
Mar 7, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Emily R LevyPeggy S Weintrub
Mar 7, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·James M McCartyJulianne E Hahn

❮ Previous
Next ❯

Citations

Apr 26, 2017·Pediatric Pulmonology·Richard AutenTerry L Noah
Nov 19, 2019·The Pediatric Infectious Disease Journal·Fouzia NaeemChokechai Rongkavilit
Nov 27, 2020·Global Pediatric Health·Alisha K Bajwa, Chokechai Rongkavilit

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Related Papers

United States Armed Forces Medical Journal
R C HUNTER, E S MONGAN
© 2021 Meta ULC. All rights reserved