Cochlear amplification and tuning depend on the cellular arrangement within the organ of Corti

Proceedings of the National Academy of Sciences of the United States of America
Hamid MotallebzadehSunil Puria

Abstract

The field of cochlear mechanics has been undergoing a revolution due to recent findings made possible by advancements in measurement techniques. While it has long been assumed that basilar-membrane (BM) motion is the most important determinant of sound transduction by the inner hair cells (IHCs), it turns out that other parts of the sensory epithelium closer to the IHCs, such as the reticular lamina (RL), move with significantly greater amplitude for weaker sounds. It has not been established how these findings are related to the complex cytoarchitecture of the organ of Corti between the BM and RL, which is composed of a lattice of asymmetric Y-shaped elements, each consisting of a basally slanted outer hair cell (OHC), an apically slanted phalangeal process (PhP), and a supporting Deiters' cell (DC). Here, a computational model of the mouse cochlea supports the hypothesis that the OHC micromotors require this Y-shaped geometry for their contribution to the exquisite sensitivity and frequency selectivity of the mammalian cochlea. By varying only the OHC gain parameter, the model can reproduce measurements of BM and RL gain and tuning for a variety of input sound levels. Malformations such as reversing the orientations of the OH...Continue Reading

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Citations

Mar 11, 2020·Journal of Biomechanical Engineering·Brissi F ZagadouDavid C Mountain
Sep 11, 2020·Scientific Reports·Mohammad ShokrianJong-Hoon Nam
Jun 22, 2019·Proceedings of the National Academy of Sciences of the United States of America·Aritra Sasmal, Karl Grosh
Nov 30, 2019·Proceedings of the National Academy of Sciences of the United States of America·Paul AvanElisabeth Verpy
Oct 21, 2020·Scientific Reports·Amir NankaliKarl Grosh
Dec 5, 2020·Trends in Hearing·Raul Sanchez-LopezTorsten Dau
May 5, 2021·The Journal of the Acoustical Society of America·Hamid Motallebzadeh, Sunil Puria
May 9, 2021·Developmental Cell·Tingfang ChenDouglas J Epstein
Jun 25, 2020·Biophysical Journal·Talat JabeenJong-Hoon Nam

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