PMID: 8951428Nov 1, 1996Paper

Cochlear integrity in rats with experimentally induced audiogenic seizure susceptibility

Hearing Research
M G Pierson, D Li

Abstract

While chronic susceptibility of rodents to audiogenic seizures (AGSs) is often accompanied by cochlear lesions, it has not been demonstrated whether cochlear hair cell losses are essential to pathogenesis in this epileptic disorder. An alternative possibility is that the neonatal timing of hearing losses is what unites various models of chronic AGS susceptibility. In the latter case, either transient or permanent hearing losses might induce susceptibility as long as they concur with a critical period of development. To address this issue, it was examined whether lesions were universally present in cochleas of adult rats after having been made susceptible to sound-triggered seizures by different types and severities of neonatal auditory trauma. Neonatal treatments included: (1) an 8 min exposure of rat pups to intense noise (125 dB SPL) on postnatal day (PND) 14; (2) injections of low doses of kanamycin (KM: 100 mg/kg) on PNDs 9-12; or (3) injections of high doses of KM (500 mg/kg) on PNDs 9-12. As adults, rats in all experimental groups, but not in sham-treated groups, exhibited sound-triggerable seizure responses. Nonetheless, this outcome did not depend on integrity of cochleas. Hair cells were rarely missing in the cochleas ...Continue Reading

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Citations

Aug 15, 2000·Neuroscience and Biobehavioral Reviews·K C Ross, J R Coleman
Jan 22, 2013·Brain Research·Guo-Run FanHong-Lian Zhang
Mar 10, 2015·Behavioural Brain Research·Natalia RybalkoJosef Syka
May 20, 1999·Developmental Psychobiology·K C Ross, J R Coleman
Dec 17, 1997·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·A G Gordon

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