Cochlear Outer-Hair-Cell Power Generation and Viscous Fluid Loss

Scientific Reports
Yanli WangSunil Puria

Abstract

Since the discovery of otoacoustic emissions and outer hair cell (OHC) motility, the fundamental question of whether the cochlea produces mechanical power remains controversial. In the present work, direct calculations are performed on power loss due to fluid viscosity and power generated by the OHCs. A three-dimensional box model of the mouse cochlea is used with a feed-forward/feed-backward approximation representing the organ of Corti cytoarchitecture. The model is fit to in vivo basilar membrane motion with one free parameter for the OHCs. The calculations predict that the total power output from the three rows of OHCs can be over three orders of magnitude greater than the acoustic input power at 10 dB sound pressure level (SPL). While previous work shows that the power gain, or the negative damping, diminishes with intensity, we show explicitly based on our model that OHC power output increases and saturates with SPL. The total OHC power output is about 2 pW at 80 dB SPL, with a maximum of about 10 fW per OHC.

References

Apr 1, 1979·The Journal of the Acoustical Society of America·C R Steele, L A Taber
Dec 1, 1992·The Journal of the Acoustical Society of America·K H Iwasa, R S Chadwick
Jul 1, 1992·The Journal of the Acoustical Society of America·J B Allen, P F Fahey
Dec 8, 1991·The Journal of Comparative Neurology·Y RaphaelR Pujol
Jan 11, 1985·Science·W E BrownellY de Ribaupierre
Jan 1, 1983·Hearing Research·H Davis
May 1, 1995·The Journal of the Acoustical Society of America·J A Tolomeo, C R Steele
Jan 1, 1994·The Journal of the Acoustical Society of America·D C Mountain, A E Hubbard
Jul 1, 1996·Biophysical Journal·J A TolomeoM C Holley
Jul 1, 1997·Biophysical Journal·K H Iwasa, M Adachi
Jun 24, 1998·The Journal of the Acoustical Society of America·E S Olson
Apr 3, 1999·Audiology & Neuro-otology·C R Steele, K M Lim
Apr 14, 1999·Proceedings of the National Academy of Sciences of the United States of America·G FrankA W Gummer
Jun 25, 1999·The Journal of the Acoustical Society of America·E de Boer, A L Nuttall
Mar 30, 2000·The Journal of the Acoustical Society of America·E de Boer, A L Nuttall
Sep 5, 2002·Hearing Research·Kian-Meng Lim, Charles R Steele
Dec 4, 2002·Proceedings of the National Academy of Sciences of the United States of America·Tianying Ren
Feb 1, 2003·The Journal of the Acoustical Society of America·Alexander A SpectorAleksander S Popel
Oct 1, 2004·Journal of Neurophysiology·Annette M Taberner, M Charles Liberman
Nov 13, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Anders FridbergerAlfred Nuttall
Apr 7, 2005·Hearing Research·Marcus MüllerJean W T Smolders
Jun 7, 2007·The Journal of the Acoustical Society of America·Sripriya RamamoorthyKarl Grosh
Jul 31, 2007·Current Biology : CB·Andrei N LukashkinIan J Russell
Aug 4, 2007·The Journal of the Acoustical Society of America·Yong-Jin YoonCharles R Steele
Jan 15, 2008·The Journal of the Acoustical Society of America·Christopher A Shera
Jul 24, 2008·The Journal of the Acoustical Society of America·Michael E RaviczJohn J Rosowski
Jul 25, 2009·PLoS Computational Biology·Richard D RabbittWilliam E Brownell
Sep 2, 2009·Biophysical Journal·Wei Dong, Elizabeth S Olson
May 21, 2010·Journal of Mechanics of Materials and Structures·Yongjin YoonCharles R Steele
Mar 3, 2011·Nature Communications·Tianying RenPeter G Gillespie
Sep 29, 2011·Journal of the Association for Research in Otolaryngology : JARO·Christopher A SheraJohn J Guinan
Nov 3, 2011·Nature Communications·Anthony W PengAnthony J Ricci
Feb 14, 2012·Biophysical Journal·Sripriya Ramamoorthy, Alfred L Nuttall
Nov 28, 2012·Hearing Research·Wei DongElizabeth S Olson
Aug 27, 2013·Biophysical Journal·Wei Dong, Elizabeth S Olson
May 29, 2014·Journal of the Association for Research in Otolaryngology : JARO·I U Teudt, C P Richter
Oct 29, 2014·Journal of the Association for Research in Otolaryngology : JARO·Joris A M SoonsSunil Puria
Mar 5, 2015·Proceedings of the National Academy of Sciences of the United States of America·Hee Yoon LeeJohn S Oghalai
Jul 8, 2015·Journal of the Association for Research in Otolaryngology : JARO·Marcel van der Heijden, Corstiaen P C Versteegh

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Citations

Aug 16, 2016·Proceedings of the National Academy of Sciences of the United States of America·Tianying RenDavid Kemp
Apr 5, 2017·The Journal of the Acoustical Society of America·Guangjian NiStephen J Elliott
May 16, 2018·Proceedings of the National Academy of Sciences of the United States of America·Hamid MotallebzadehSunil Puria
Sep 3, 2017·The Journal of the Acoustical Society of America·Stephen J ElliottLuyang Sun
Mar 11, 2020·Journal of Biomechanical Engineering·Brissi F ZagadouDavid C Mountain
Aug 28, 2020·Proceedings of the National Academy of Sciences of the United States of America·Richard D Rabbitt
Sep 8, 2017·PLoS Computational Biology·Yanju LiuJong-Hoon Nam
Sep 11, 2020·Scientific Reports·Mohammad ShokrianJong-Hoon Nam
Jun 22, 2019·Proceedings of the National Academy of Sciences of the United States of America·Aritra Sasmal, Karl Grosh
Feb 8, 2018·Biophysical Journal·Thomas Bowling, Julien Meaud
May 5, 2021·The Journal of the Acoustical Society of America·Hamid Motallebzadeh, Sunil Puria
Jun 1, 2018··Kuni H. Iwasa, Kuni H. Iwasa

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