PMID: 15241232Jul 9, 2004Paper

Cochleosaccular dysplasia: a morphometric and histopathologic study in a series of temporal bones

Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
Andre L L SampaioCarlos A C P Oliveira

Abstract

The objective of this study was to perform a morphometric analysis of a series of temporal bones with cochleosaccular dysplasia to clarify the extent of inner ear changes in this disease. This human temporal bone histopathologic study of a series of deaf-mute cases involves morphometric analysis, including stria vascularis and spiral ligament area measurements and spiral ganglion and hair cells counts. Thirteen temporal bones were selected from 35 with deaf mutism based on the histopathologic findings described by Scheibe. Twenty normal age-matched control subjects were used for comparisons. All temporal bones had the main histopathologic findings described by Scheibe, as well as severe affected stria vascularis. Seven temporal bones had cystic areas in the stria and three had concretions. Cross-sectional strial areas in temporal bones with cochleosaccular dysplasia were smaller than normal in all cochlear turns; however, no difference was found in spiral ligament cross-sectional areas. Reissner's membrane was hydropic in three temporal bones and the organ of Corti was absent in at least one cochlear turn in five. Concretions were present in the macula of seven temporal bones. Twelve temporal bones showed some level of spiral g...Continue Reading

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Citations

Jun 15, 2010·International Journal of Pediatric Otorhinolaryngology·Andre L L SampaioMichael M Paparella
Sep 19, 2012·The Journal of Comparative Neurology·Luis Óscar Sánchez-GuardadoMatías Hidalgo-Sánchez

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