PMID: 16614396Apr 15, 2006Paper

Cocoa polyphenols inhibit phorbol ester-induced superoxide anion formation in cultured HL-60 cells and expression of cyclooxygenase-2 and activation of NF-kappaB and MAPKs in mouse skin in vivo

The Journal of Nutrition
Ki Won LeeYoung-Joon Surh

Abstract

We investigated the antioxidant and antiinflammatory activities of a flavonoid-rich polyphenolic fraction of cocoa. Cocoa polyphenol (CP) was fractionated from commercial cocoa powder and contained 468 mg/g of gallic acid-equivalent phenolics and 413 mg/g epicatechin-equivalent flavonoids. CP exhibited a dose-dependent free radical-scavenging activity as determined by both 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) and 2,2'-diphenyl-1-picrylhydrazyl radical scavenging assays. CP also dose-dependently inhibited xanthine oxidase activity and 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced superoxide-anion generation in cultured human promyeolcytic leukemia HL-60 cells. Oral administering of CP (4, 20, 40, and 200 mg/kg body weight) to ICR mice 1 h prior to TPA (10 nmol) inhibited ear edema at 5 h in a dose-dependent manner. The levels of COX-2 expression induced in mouse skin after 4-h treatment with topical TPA (10 nmol) was also diminished significantly by pretreating CP (40 or 200 mg/kg) for 30 min. CP at the same doses inhibited TPA-induced nuclear translocation of p65 and subsequent DNA binding of NF-kappaB at 1 h by blocking the degradation of IkappaBalpha in mouse skin. Moreover, phosphorylation of p38 mitoge...Continue Reading

References

Jan 25, 1985·Science·P A Cerutti
Jan 1, 1995·Proceedings of the Society for Experimental Biology and Medicine·H WeiY Wang
Dec 2, 1999·FEBS Letters·G E Arteel, H Sies
Dec 22, 1999·Journal of Agricultural and Food Chemistry·J A VinsonL Zubik
Jun 13, 2002·Journal of Agricultural and Food Chemistry·Dae-Ok KimChang Yong Lee
Jul 5, 2002·The Journal of Nutrition·Tankred ScheweHelmut Sies
Sep 11, 2002·Proceedings of the National Academy of Sciences of the United States of America·Karin Muller-DeckerGerhard Furstenberger
Dec 20, 2002·Nature·Lisa M Coussens, Zena Werb
Aug 29, 2003·Nature·Mauro SerafiniAlan Crozier
Oct 23, 2003·Nature Reviews. Cancer·Young-Joon Surh
Dec 3, 2003·Journal of Agricultural and Food Chemistry·Ki Won LeeChang Yong Lee
Apr 29, 2004·The American Journal of Clinical Nutrition·Claudine ManachLiliana Jiménez
Oct 19, 2004·Seminars in Cancer Biology·Mary PhilipHans Schreiber
Mar 4, 2005·Archives of Pharmacal Research·Young-Joon Surh, Joydeb Kumar Kundu
Mar 10, 2005·The American Journal of Clinical Nutrition·Cesar G Fraga
Jun 1, 2005·Trends in Pharmacological Sciences·Chi Chen, Ah-Ng Tony Kong

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Citations

Feb 10, 2009·Molecular Nutrition & Food Research·Ji-Young BaeYoung-Hee Kang
Mar 4, 2014·Critical Reviews in Food Science and Nutrition·Jiyoung KimHyong Joo Lee
Nov 25, 2014·Molecular Nutrition & Food Research·Estanislau NavarroHelmut Schröder
Jul 17, 2015·The American Journal of Clinical Nutrition·Mark D FarrarLesley E Rhodes
Jul 14, 2017·Frontiers in Nutrition·Mariona Camps-BossacomaMargarida Castell
Feb 6, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·María Del Carmen Villegas-AguilarAntonio Segura-Carretero
Jun 4, 2008·The Journal of Biological Chemistry·Nam Joo KangZigang Dong
Sep 9, 2009·Journal of Cosmetic Dermatology·Stefanie WilliamsCarmel Lally
Nov 22, 2013·Molecular Nutrition & Food Research·Faisal AliSander Kersten
Apr 8, 2011·Antioxidants & Redox Signaling·David L KatzAther Ali
May 30, 2012·International Journal of Obesity : Journal of the International Association for the Study of Obesity·S Y MinK W Lee
Aug 25, 2009·Journal of Cardiovascular Pharmacology·Monica GalleanoCesar G Fraga
Aug 15, 2014·Nutrients·Giovanni ScapagniniSalvador Gonzalez
Jan 8, 2009·The British Journal of Nutrition·Emma Ramiro-Puig, Margarida Castell
Apr 14, 2015·The Journal of Dermatological Treatment·William TuongRaja K Sivamani
Jan 8, 2015·Frontiers in Pharmacology·Paulo ZielinskyIzabele Vian
Aug 14, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Annayara Celestina Ferreira FernandesGabriela Alves Macedo
Jan 1, 2016·Comprehensive Reviews in Food Science and Food Safety·Ana Clara AprotosoaieAnca Miron
Jun 6, 2009·Journal of Agricultural and Food Chemistry·Min-Hsiung PanChi-Tang Ho

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