Abstract
Increasing prevalence of obesity and metabolic syndrome warrants identification of potential therapeutic options for intervention. This study tested commercially available Virgin Coconut Oil and Coconut Nourish, as coconuts are rich sources of lauric and myristic acids. Male Wistar rats were fed either corn starch diet (C); high-carbohydrate, high-fat diet (H); high-carbohydrate, high-virgin coconut oil diet (HV); or high-carbohydrate, high-coconut Nourish diet (HN) for 16 weeks. Metabolic, liver, and cardiovascular health parameters were measured during and at the end of the study. Virgin coconut oil lowered body weight (C 386±8g, H 516±13g, HV 459±10g), blood glucose concentrations (C 4.2±0.1 mmol/L, H 5.4±0.2 mmol/L, HV 4.6±0.2 mmol/L), systolic blood pressure (C 127±5mmHg, H 149±4mmHg, HV 133±3mmHg,) and diastolic stiffness (C 25.0±1.7, H 31.4±1.2, HV 25.2±2.3,) with improved structure and function of the heart and liver. Coconut Nourish increased total body lean mass (C 255±10g, H 270±16g, HN 303±15g) and lowered plasma total cholesterol concentrations (C 1.6±0.2 mmol/L, H 1.7±0.1 mmol/L, HN 1.0±0.0 mmol/L), systolic blood pressure (C 127±5mmHg, H 149±4mmHg, HN 130±3mmHg) and diastolic stiffness (C 25.0±1.7, H 31.4±1.2, HN...Continue Reading
References
Nov 1, 1992·The American Journal of Clinical Nutrition·M A Denke, S M Grundy
Apr 1, 1994·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·P L ZockM B Katan
Mar 1, 1996·The British Journal of Nutrition·M BaggerK R Ryttig
Oct 27, 1999·Metabolism: Clinical and Experimental·S LindebergB Ahrén
Sep 30, 2000·The American Journal of Clinical Nutrition·J P DeLanyG A Bray
Mar 7, 2002·The Journal of Nutrition·Marie-Pierre St-Onge, Peter J H Jones
Jun 15, 2006·The Journal of Nutrition·Clémence BlouetJean-François Huneau
Jun 19, 2009·Molecular and Cellular Biochemistry·Linda T TranJohn H McNeill
Aug 28, 2009·The Journal of Nutrition·Julia R DiBelloAna Baylin
Sep 26, 2009·Journal of Cellular Physiology·Sandro M HirabaraPierre Maechler
Oct 23, 2010·Journal of Cardiovascular Pharmacology·Sunil K PanchalLindsay Brown
Mar 25, 2011·The Journal of Nutritional Biochemistry·Hemant PoudyalLindsay Brown
Jul 21, 2011·Asian Pacific Journal of Tropical Medicine·Manisha DebMandal, Shyamapada Mandal
Mar 16, 2013·Advances in Nutrition·James M Rippe, Theodore J Angelopoulos
May 16, 2013·Advances in Nutrition·Glen D Lawrence
May 13, 2014·Human Reproduction·Uche EzehRicardo Azziz
Nov 20, 2014·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·S O'Neill, L O'Driscoll
Feb 11, 2015·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Naiane F B AlvesValdir A Braga
Feb 26, 2015·Journal of Hypertension·Alice Victoria Klein, Hosen Kiat
Apr 9, 2015·Pharmaceutical Biology·Yusof KamisahHj Mohd Saad Qodriyah
Apr 19, 2015·BMC Complementary and Alternative Medicine·David A AkinpeluAnthony I Okoh
Jul 25, 2015·Progress in Lipid Research·Hemant Poudyal, Lindsay Brown
Aug 21, 2015·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·E B C LimaS M M Vasconcelos
Sep 9, 2015·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·L BrownS K Panchal
Jan 1, 2016·Lipids·Shatha HammadPeter J Jones
Feb 10, 2016·Journal of Natural Medicines·Eliane Brito Cortez LimaSilvânia Maria Mendes Vasconcelos
Mar 8, 2016·Nutrition Reviews·Laurence EyresRachel C Brown
Sep 30, 2016·Plant Foods for Human Nutrition·Devi Lekshmi SheelaAchuthan C Raghavamenon
Apr 19, 2017·Scientific Reports·Sunderajhan SekarYin Xiao
Aug 18, 2017·Journal of Dietary Supplements·Ademola C FamurewaGoodness C Ezechukwu
Aug 23, 2017·Experimental Cell Research·Satoko ShinjoNobuhito Goda
Sep 2, 2017·Journal of the Science of Food and Agriculture·Arunaksharan NarayanankuttyAchuthan C Raghavamenon
Citations
Apr 25, 2019·Physiological Reports·Benjamin GollaschFriedrich C Luft
Sep 1, 2018·Plant Foods for Human Nutrition·Sinisa DjurasevicDragana Mitic-Culafic
Jul 6, 2018·Current Nutrition Reports·Senthilkumar Sankararaman, Thomas J Sferra
Jan 10, 2021·Scientific Reports·Klara LalouckovaLadislav Kokoska
Oct 29, 2020·Scientific Reports·Eric S GoetzmanSatdarshan P Monga