Cocrystal structure of YY1 bound to the adeno-associated virus P5 initiator

Proceedings of the National Academy of Sciences of the United States of America
H B HoubaviyS K Burley

Abstract

Ying-Yang 1 protein (YY1) supports specific, unidirectional initiation of messenger RNA production by RNA polymerase II from two adjacent start sites in the adeno-associated virus P5 promoter, a process which is independent of the TATA box-binding protein (TBP). The 2.5-A resolution YY1-initiator element cocrystal structure reveals four zinc fingers recognizing a YY1-binding consensus sequence. Upstream of the transcription start sites protein-DNA contacts involve both strands and downstream they are virtually restricted to the template strand, permitting access to the active center of RNA polymerase II and ensuring specificity and directionality. The observed pattern of protein-DNA contacts also explains YY1 binding to a preformed transcription bubble, and YY1 binding to a DNA/RNA hybrid analog of the P5 promoter region containing a nascent RNA transcript. A model is proposed for YY1-directed, TBP-independent transcription initiation.

References

Jan 1, 1990·Methods in Enzymology·F W StudierJ W Dubendorff
Apr 7, 1989·Cell·S T Smale, D Baltimore
Jan 1, 1988·Advances in Protein Chemistry·S K Burley, G A Petsko
Jun 20, 1988·Journal of Molecular Biology·M Levitt, M F Perutz
May 5, 1986·Journal of Molecular Biology·F W Studier, B A Moffatt
Dec 22, 1986·Nucleic Acids Research·P Bucher, E N Trifonov
Nov 11, 1995·Nucleic Acids Research·R P Hyde-DeRuyscherT Shenk
Apr 14, 1995·Science·Y Shi, J M Berg
Sep 14, 1995·Nature·D B NikolovS K Burley
Apr 1, 1994·Current Biology : CB·G Gill
Jul 19, 1994·Proceedings of the National Academy of Sciences of the United States of America·L Nekludova, C O Pabo
Apr 1, 1994·Molecular and Cellular Biology·C E DabrowskiP A Schaffer
Jan 1, 1994·Molecular and Cellular Biology·R JavaheryS T Smale
Dec 1, 1993·Genes & Development·S Natesan, M Z Gilman
May 6, 1993·Nature·A R Ferré-D'AmaréS K Burley
Feb 1, 1996·Current Opinion in Structural Biology·S K Burley
Jan 1, 1996·Annual Review of Biochemistry·S K Burley, R G Roeder
Nov 26, 1996·Proceedings of the National Academy of Sciences of the United States of America·H B HoubaviyS K Burley
Mar 1, 1992·Current Biology : CB·S Hahn

❮ Previous
Next ❯

Citations

Jan 1, 1997·Biopolymers·R E Dickerson, T K Chiu
Feb 7, 2008·Cell Biochemistry and Biophysics·Kathryn J Brayer, David J Segal
Nov 26, 2003·Journal of Molecular Biology·Javier Fernández-MartínezEduardo A Espeso
Feb 1, 1997·Current Opinion in Structural Biology·Y Choo, A Klug
Mar 31, 1998·Current Opinion in Structural Biology·S Tan, T J Richmond
Sep 13, 2001·Bioorganic & Medicinal Chemistry·K Matsushita, Y Sugiura
Dec 12, 2013·Nature Communications·Yanan CaoGuang Ning
Aug 19, 2010·Nature Reviews. Genetics·Fyodor D UrnovPhilip D Gregory
Jan 1, 1997·Nature Structural Biology
Apr 18, 1998·Nature Structural Biology·Y Choo, J W Schwabe
May 17, 2011·Physical Biology·Anton V Persikov, Mona Singh
Feb 28, 1998·Nucleic Acids Research·N M LuscombeJ M Thornton
Apr 25, 2000·Nucleic Acids Research·M SchaubP Carbon
Feb 28, 2002·Nucleic Acids Research·Zdenek MorávekBohdan Schneider
Mar 9, 2004·Nucleic Acids Research·Chu H ChoiAnny Usheva
May 5, 2007·Nucleic Acids Research·Jeong Do KimJoomyeong Kim
Jun 29, 1999·Cold Spring Harbor Symposia on Quantitative Biology·L B Rothman-DenesK Kazmierczak
Sep 29, 2005·Journal of Virology·Jaewook Oh, Steven S Broyles
Jun 8, 2001·Annual Review of Biochemistry·C O PaboR A Grant
Jan 1, 1997·Annual Review of Biophysics and Biomolecular Structure·G Patikoglou, S K Burley
Feb 20, 2010·BMC Evolutionary Biology·Minoru Hatayama, Jun Aruga
Dec 19, 2012·Human Genomics·Konstantinos SousounisPanagiotis A Tsonis
Jan 24, 2013·PLoS Computational Biology·Kristy Nowak-LovatoBoian S Alexandrov
Jan 18, 2012·Critical Reviews in Oncogenesis·Weidong ZhuHermes Garbán
Jun 11, 2014·Acta Crystallographica. Section D, Biological Crystallography·Kevin PröpperIsabel Usón
Dec 13, 2006·Proceedings of the National Academy of Sciences of the United States of America·Frank H WilkinsonMichael L Atchison
Mar 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·D J SegalC F Barbas
Nov 26, 1996·Proceedings of the National Academy of Sciences of the United States of America·H B HoubaviyS K Burley
May 13, 1997·Proceedings of the National Academy of Sciences of the United States of America·D A LeonardT K Kerppola
Feb 14, 2014·Nucleic Acids Research·Ankit GuptaGary D Stormo
Oct 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·J H LaityP E Wright
Apr 18, 1998·Proceedings of the National Academy of Sciences of the United States of America·R T NolteR S Brown
Nov 26, 1996·Proceedings of the National Academy of Sciences of the United States of America·A Usheva, T Shenk

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell-Type Specific Viral Vectors

Viral vectors are used in biological research and therapy to deliver genetic material into cells. However, the efficiency of viral vectors varies depending on the cell type. Here is the latest research on cell-type-specific viral vectors.

Cell-Type-Specific Viral Vectors (ASM)

Viral vectors are used in biological research and therapy to deliver genetic material into cells. However, the efficiency of viral vectors varies depending on the cell type. Here is the latest research on cell-type-specific viral vectors.

Cell-Type-Specific Viral Vectors

Viral vectors are used in biological research and therapy to deliver genetic material into cells. However, the efficiency of viral vectors varies depending on the cell type. Here is the latest research on cell-type-specific viral vectors.