Coculture with homologous oviductal cells improved the implantation of human embryos--a prospective randomized control trial

Journal of Assisted Reproduction and Genetics
W S YeungP c Ho

Abstract

The efficacy of homologous oviductal cell coculture on the success of a human in vitro fertilization program was investigated in a prospective randomized control clinical trial. One hundred eighty-one couples were randomized into the control and the coculture groups. Pronuclear-stage zygotes were either cultured in Earles' balanced salt solution supplemented with 15% preovulatory serum (control) or cultured with human oviductal cells (coculture) for 24 hr before embryo transfer. There was no difference in the age of the patients, indication for treatment, number of oocyte retrieved or fertilized, or number of embryo replaced between the two groups. The pregnancy rates per transfer for the control and the coculture group were 12.8 and 19.3%, respectively. The number of viable fetus was significantly higher (P < 0.01, chi-square test) in the coculture group (25/264) than in the control group (8/262). The coculture group also showed a higher multiple pregnancy rate, lower abortion rate, and more spare embryos suitable for cryopreservation.

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Citations

Sep 15, 2012·Journal of Assisted Reproduction and Genetics·Alex Simon, Neri Laufer
Mar 2, 2002·Fertility and Sterility·Christine Briton-JonesChristopher Haines
May 8, 2008·Current Opinion in Obstetrics & Gynecology·Kevin S Richter
Apr 9, 2009·Current Opinion in Obstetrics & Gynecology·Hulusi Bulent Zeyneloglu, Semra Kahraman
Nov 4, 2000·Biochemical and Biophysical Research Communications·K F LeeW S Yeung
Sep 30, 2006·Human Fertility : Journal of the British Fertility Society·Kai-Fai Lee, William S B Yeung
May 20, 2005·Reproductive Biomedicine Online·Bulent Urman, Basak Balaban
May 21, 2008·Fertility and Sterility·Namita KattalLarry I Barmat
Feb 7, 2007·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Anamika SenguptaRajagopala Sridaran
Jul 27, 2001·Molecular Reproduction and Development·Y L LeeW S Yeung
Sep 1, 2012·Reproduction, Fertility, and Development·Ahmed AldarmahiAlireza Fazeli
Mar 22, 2002·Biochemical and Biophysical Research Communications·Kai-Fai LeeWilliam S B Yeung

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