PMID: 8581836Nov 1, 1995Paper

Codeine-induced histamine release in intact human skin monitored by skin microdialysis technique: comparison of intradermal injections with an atraumatic intraprobe drug delivery system

Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
L J PetersenP S Skov

Abstract

The skin microdialysis technique makes it possible to measure histamine release in intact human skin in vivo directly. In this study we have used the microdialysis technique to characterize histamine release by codeine after intracutaneous injections and following skin challenge by a novel atraumatic delivery technique. The purpose of the study was to compare histamine release in human skin by codeine, delivered by an intraprobe drug delivery system (IPD) and intracutaneous injections (ICT), with respect to dose-response relations, kinetics of histamine appearance and decay, correlations between histamine release and skin responses, and reproducibility. Hollow dialysis fibres were inserted intradermally in 12 healthy subjects. Twelve fibres were inserted in each subject, six fibres in each arm. Each fibre was perfused at a rate of 3 microM/min, and samples were collected in 2 min fractions. By the IPD technique, codeine was administered to the skin by adding codeine to the perfusion medium. Sequential IPD challenges were performed in one arm, and ICTs were done on the other arm. Sixfold serial dilutions of codeine (0.01-3 mg/mL) caused a significant dose-related histamine release by ICT and IPD. Peak histamine release was found...Continue Reading

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Citations

Sep 1, 1996·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·M PerzanowskaM K Church
Mar 7, 2009·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Lars J PetersenHenrik Kehlet
Feb 15, 2013·Journal of Anesthesia·Norma J Klein, Shad Misseldine
Dec 8, 2000·Advanced Drug Delivery Reviews·M Müller
May 7, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M SchmelzR Rukwied
Jun 8, 2001·European Journal of Pain : EJP·G LischetzkiM Schmelz
May 17, 2006·The Journal of Investigative Dermatology·Chris D Anderson
Jan 11, 2007·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·K SchererA J Bircher
Mar 29, 2006·Journal of Pharmacological and Toxicological Methods·Christian HöchtCarlos A Taira
Mar 1, 1997·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·L J PetersenP S Skov
Jun 12, 2013·Skin Pharmacology and Physiology·L MelgaardL J Petersen
Dec 31, 1997·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M K Church
Aug 1, 1997·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·L J PetersenP S Skov
Jan 1, 1996·Drug Delivery·T L Whateley

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