Codelivery of a tea extract prevents morbidity and mortality associated with oral vanadate therapy in streptozotocin-induced diabetic rats

Metabolism: Clinical and Experimental
Tod A ClarkGrant N Pierce

Abstract

Oral administration of vanadate has a strong hypoglycemic effect but results in toxic side effects like life-threatening diarrhea. Tea is known to have potent antidiarrhea effects. We investigated the potential of suspending the vanadate in a tea decoction to reduce the diarrheatic action of vanadate. A concentrated extract of Lichee black tea was, therefore, added to sodium orthovanadate. Streptozotocin (STZ)-induced diabetic rats were orally gavaged with vanadate suspended in water or in the tea decoction, or with the tea extract alone. Blood glucose levels were assessed daily over 11 weeks with levels greater than 10 mmol/L warranting therapeutic intervention. Both the vanadate/water and vanadate/tea solutions acutely reduced blood glucose. The tea extract alone had no effect. The majority of vanadate/water-treated rats developed diarrhea and mortality rates approached 40%. Vanadate/tea-treated diabetic rats experienced no diarrhea or mortality and liver and kidney analyses (plasma ALT and creatinine, blood urea nitrogen [BUN], and urine-specific gravity) were normal. Animals treated with vanadate/tea retained blood glucose levels less than 10 mmol/L for an average of 24 consecutive days without subsequent treatments. Catara...Continue Reading

References

Nov 1, 1984·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·M H TanG Pierce
Aug 1, 1982·Biochemical and Biophysical Research Communications·G SwarupD L Garbers
Sep 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·G N PierceN S Dhalla
Mar 1, 1993·Endeavour·Y Shechter, A Shisheva
Jan 1, 1995·The Netherlands Journal of Medicine·R P Dullaart
Jun 1, 1996·Endocrinology and Metabolism Clinics of North America·A S KrolewskiM B Freire
Jun 1, 1996·Endocrinology and Metabolism Clinics of North America·C Arauz-Pacheco, P Raskin
Dec 1, 1996·Critical Reviews in Biochemistry and Molecular Biology·N SekarY Shechter
Oct 1, 1996·Diabetes Research and Clinical Practice·D G Marrero, S K Kraft
Oct 23, 1997·Current Opinion in Neurology·H Andersen, J Jakobsen
Nov 5, 1997·Diabetologia·A A SimaA Vinik
Dec 16, 1997·Mineral and Electrolyte Metabolism·P CastellinoA Solini
Aug 26, 1998·The Medical Clinics of North America·I B Hirsch
Dec 16, 1998·Current Opinion in Neurology·G Comi, M Corbo
Jun 25, 1999·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·V BadmaevM Majeed
Jun 26, 1999·Journal of Toxicology. Clinical Toxicology·D G Barceloux
Sep 4, 1999·BioFactors·K H Thompson
Mar 21, 2000·Molecular and Cellular Biochemistry·J L Domingo
Jun 6, 2000·Molecular and Cellular Biochemistry·A K Srivastava
Jun 14, 2000·Drugs·J D Best, D N O'Neal
Jul 27, 2000·American Journal of Physiology. Endocrinology and Metabolism·Q SunY Shechter

❮ Previous
Next ❯

Citations

May 13, 2008·Journal of Clinical Child and Adolescent Psychology : the Official Journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53·Jennifer JonesRenee D Goodwin
Dec 2, 2004·Canadian Journal of Physiology and Pharmacology·Tod A ClarkGrant N Pierce
Feb 23, 2013·Heart Failure Reviews·Tod A ClarkGrant N Pierce
Apr 24, 2008·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Xueqin MaoYujing Tang
Jul 8, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·L ZhangZ L Xia
Jan 21, 2006·Metabolism: Clinical and Experimental·Andrea L EdelGrant N Pierce

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.