Codelivery of SH-aspirin and curcumin by mPEG-PLGA nanoparticles enhanced antitumor activity by inducing mitochondrial apoptosis

International Journal of Nanomedicine
Lin ZhouXiang Li

Abstract

Natural product curcumin (Cur) and H2S-releasing prodrug SH-aspirin (SH-ASA) are potential anticancer agents with diverse mechanisms, but their clinical application prospects are restricted by hydrophobicity and limited efficiency. In this work, we coencapsulated SH-ASA and Cur into methoxy poly(ethylene glycol)-poly (lactide-coglycolide) (mPEG-PLGA) nanoparticles through a modified oil-in-water single-emulsion solvent evaporation process. The prepared SH-ASA/Cur-coloaded mPEG-PLGA nanoparticles had a mean particle size of 122.3±6.8 nm and were monodispersed (polydispersity index =0.179±0.016) in water, with high drug-loading capacity and stability. Intriguingly, by treating with SH-ASA/Cur-coloaded mPEG-PLGA nanoparticles, obvious synergistic anticancer effects on ES-2 and SKOV3 human ovarian carcinoma cells were observed in vitro, and activation of the mitochondrial apoptosis pathway was indicated. Our results demonstrated that SH-ASA/Cur-coloaded mPEG-PLGA nanoparticles could have potential clinical advantages for the treatment of ovarian cancer.

Citations

Feb 27, 2017·Applied Biochemistry and Biotechnology·Mahboubeh EbrahimianMaryam Hashemi
Sep 29, 2017·Artificial Cells, Nanomedicine, and Biotechnology·Maryam AfsharzadehMohammad Ramezani
May 21, 2019·Journal of Biomaterials Applications·Peng HeXiaolu Li
May 8, 2019·Journal of Liposome Research·Intouch SakpakdeejaroenChristine Dufès
Dec 29, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Nanasaheb D ThoratJoanna Bauer
Nov 6, 2020·Journal of Ovarian Research·Mohammad Hossein PourhanifehHamed Mirzaei
May 3, 2019·Pharmacology & Therapeutics·Tanweer HaiderVandana Soni
May 27, 2021·Advances in Pharmacological and Pharmaceutical Sciences·Pouria Rahmanian-DevinVahid Reza Askari

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Methods Mentioned

BETA
protein assay
electrophoresis
flow cytometry

Software Mentioned

SPSS

Related Concepts

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis