Coding coenzyme handles: a hypothesis for the origin of the genetic code
Proceedings of the National Academy of Sciences of the United States of America
Nov 1, 1993
Eörs Szathmáry
PMID: 8234335
Get paper from
Abstract
The coding coenzyme handle hypothesis suggests that useful coding preceded translation. Early adapters, the ancestors of present-day anticodons, were charged with amino acids acting as coenzymes of ribozymes in a metabolically complex RNA world. The ancestral aminoacyl-adapter synthetas...read more
Mentioned in this Paper
Amino Acyl-tRNA Synthetases
Catalytic RNA
Coenzymes
Transfer RNA
Introns
Genetic Code
Biological Evolution
Paper Details
References
- References58
- Citations56
A specific amino acid binding site composed of RNA
ScienceJune 24, 1988Michael Yarus29
Natural selection, protein engineering, and the last riboorganism: rational model building in biochemistry
Cold Spring Harbor Symposia on Quantitative BiologyJanuary 1, 1987Steven A. BennerJoseph Anthony Piccirilli
The extension reached by the minimization of the polarity distances during the evolution of the genetic code
Journal of Molecular EvolutionOctober 1, 1989Massimo Di Giulio141Rapid determination of nucleotides that define tRNA(Gly) acceptor identity
Proceedings of the National Academy of Sciences of the United States of AmericaJuly 15, 1991William H McClainJohn Schneider
RNA substrate binding site in the catalytic core of the Tetrahymena ribozyme
NatureJuly 9, 1992Anna Marie PyleThomas R. Cech22
Intron phylogeny: a new hypothesis
Trends in Genetics : TIGMay 1, 1991Thomas Cavalier-Smith
Genetic code development by stop codon takeover
Journal of Theoretical BiologyNovember 21, 1988Niles Lehman, Timothy N JukesStriking effects of coupling mutations in the acceptor stem on recognition of tRNAs by Escherichia coli Met-tRNA synthetase and Met-tRNA transformylase
Proceedings of the National Academy of Sciences of the United States of AmericaOctober 1, 1992C L LeeUttam Lal RajBhandary171The formation of peptides from glycine thioesters
Journal of Molecular EvolutionOctober 1, 1979Arthur L Weber, Leslie E OrgelSelf-splicing introns in tRNA genes of widely divergent bacteria
NatureMay 14, 1992B Reinhold-Hurek, David A Shub
12345...
- References58
- Citations56
The scenario on the origin of translation in the RNA world: in principle of replication parsimony
Biology DirectNovember 27, 2010Wentao Ma601
The beta-sheets of proteins, the biosynthetic relationships between amino acids, and the origin of the genetic code
Origins of Life and Evolution of the Biosphere : the Journal of the International Society for the Study of the Origin of LifeDecember 1, 1996Massimo Di GiulioModern diversification of the amino acid repertoire driven by oxygen
Proceedings of the National Academy of Sciences of the United States of AmericaDecember 21, 2017Matthias GranoldBernd Moosmann8114282The phylogeny of tRNAs seems to confirm the predictions of the coevolution theory of the origin of the genetic code
Origins of Life and Evolution of the Biosphere : the Journal of the International Society for the Study of the Origin of LifeDecember 1, 1995Massimo Di GiulioAre proposed early genetic codes capable of encoding viable proteins?
Journal of Molecular EvolutionMay 1, 2014Annamária Franciska AngyánZoltán GáspáriWas Wright right? The canonical genetic code is an empirical example of an adaptive peak in nature; deviant genetic codes evolved using adaptive bridges
Journal of Molecular EvolutionAugust 1, 2010David M Seaborg
Pseudogene rescue: an adaptive mechanism of codon reassignment
Journal of Evolutionary BiologyAugust 1, 2010Louise J Johnson28
Small cofactors may assist protein emergence from RNA world: clues from RNA-protein complexes
PloS OneJuly 18, 2011Liang Shen, Hong-Fang Ji1231
On the coevolution of genes and genetic code
GeneDecember 5, 2005Hani GoodarziNoorossadat Torabi
Some introductory formalizations on the affine Hilbert spaces model of the origin of life. I. On quantum mechanical measurement and the origin of the genetic code: a general physical framework theory
Bio SystemsAugust 1, 2006András Balázs
12345...
Related Papers
Amino acids as RNA ligands: a direct-RNA-template theory for the code's origin
Journal of Molecular EvolutionJuly 1, 1998
Michael Yarus
On concerted origin of transfer RNAs with complementary anticodons
Origins of Life and Evolution of the Biosphere : the Journal of the International Society for the Study of the Origin of LifeDecember 1, 1993
Sergei N RodinA Rodin
Coding coenzyme handles: a hypothesis for the origin of the genetic code
Proceedings of the National Academy of Sciences of the United States of America
Nov 1, 1993
Eörs Szathmáry
PMID: 8234335
Abstract
The coding coenzyme handle hypothesis suggests that useful coding preceded translation. Early adapters, the ancestors of present-day anticodons, were charged with amino acids acting as coenzymes of ribozymes in a metabolically complex RNA world. The ancestral aminoacyl-adapter synthetas...read more
Mentioned in this Paper
Amino Acyl-tRNA Synthetases
Catalytic RNA
Coenzymes
Transfer RNA
Introns
Related Papers
Paper Details
References
- References58
- Citations56
A specific amino acid binding site composed of RNA
ScienceJune 24, 1988Michael Yarus29Natural selection, protein engineering, and the last riboorganism: rational model building in biochemistry
Cold Spring Harbor Symposia on Quantitative BiologyJanuary 1, 1987Steven A. BennerJoseph Anthony PiccirilliThe extension reached by the minimization of the polarity distances during the evolution of the genetic code
Journal of Molecular EvolutionOctober 1, 1989Massimo Di Giulio141Rapid determination of nucleotides that define tRNA(Gly) acceptor identity
Proceedings of the National Academy of Sciences of the United States of AmericaJuly 15, 1991William H McClainJohn SchneiderRNA substrate binding site in the catalytic core of the Tetrahymena ribozyme
NatureJuly 9, 1992Anna Marie PyleThomas R. Cech22Intron phylogeny: a new hypothesis
Trends in Genetics : TIGMay 1, 1991Thomas Cavalier-SmithGenetic code development by stop codon takeover
Journal of Theoretical BiologyNovember 21, 1988Niles Lehman, Timothy N JukesStriking effects of coupling mutations in the acceptor stem on recognition of tRNAs by Escherichia coli Met-tRNA synthetase and Met-tRNA transformylase
Proceedings of the National Academy of Sciences of the United States of AmericaOctober 1, 1992C L LeeUttam Lal RajBhandary171The formation of peptides from glycine thioesters
Journal of Molecular EvolutionOctober 1, 1979Arthur L Weber, Leslie E OrgelSelf-splicing introns in tRNA genes of widely divergent bacteria
NatureMay 14, 1992B Reinhold-Hurek, David A Shub
12345...
- References58
- Citations56
The scenario on the origin of translation in the RNA world: in principle of replication parsimony
Biology DirectNovember 27, 2010Wentao Ma601The beta-sheets of proteins, the biosynthetic relationships between amino acids, and the origin of the genetic code
Origins of Life and Evolution of the Biosphere : the Journal of the International Society for the Study of the Origin of LifeDecember 1, 1996Massimo Di GiulioModern diversification of the amino acid repertoire driven by oxygen
Proceedings of the National Academy of Sciences of the United States of AmericaDecember 21, 2017Matthias GranoldBernd Moosmann8114282The phylogeny of tRNAs seems to confirm the predictions of the coevolution theory of the origin of the genetic code
Origins of Life and Evolution of the Biosphere : the Journal of the International Society for the Study of the Origin of LifeDecember 1, 1995Massimo Di GiulioAre proposed early genetic codes capable of encoding viable proteins?
Journal of Molecular EvolutionMay 1, 2014Annamária Franciska AngyánZoltán GáspáriWas Wright right? The canonical genetic code is an empirical example of an adaptive peak in nature; deviant genetic codes evolved using adaptive bridges
Journal of Molecular EvolutionAugust 1, 2010David M SeaborgPseudogene rescue: an adaptive mechanism of codon reassignment
Journal of Evolutionary BiologyAugust 1, 2010Louise J Johnson28Small cofactors may assist protein emergence from RNA world: clues from RNA-protein complexes
PloS OneJuly 18, 2011Liang Shen, Hong-Fang Ji1231On the coevolution of genes and genetic code
GeneDecember 5, 2005Hani GoodarziNoorossadat TorabiSome introductory formalizations on the affine Hilbert spaces model of the origin of life. I. On quantum mechanical measurement and the origin of the genetic code: a general physical framework theory
Bio SystemsAugust 1, 2006András Balázs
12345...
Get paper from