Coding of level of ambiguity within neural systems mediating choice

Frontiers in Neuroscience
Dan Lopez-Paniagua, Carol A Seger

Abstract

Data from previous neuroimaging studies exploring neural activity associated with uncertainty suggest varying levels of activation associated with changing degrees of uncertainty in neural regions that mediate choice behavior. The present study used a novel task that parametrically controlled the amount of information hidden from the subject; levels of uncertainty ranged from full ambiguity (no information about probability of winning) through multiple levels of partial ambiguity, to a condition of risk only (zero ambiguity with full knowledge of the probability of winning). A parametric analysis compared a linear model in which weighting increased as a function of level of ambiguity, and an inverted-U quadratic models in which partial ambiguity conditions were weighted most heavily. Overall we found that risk and all levels of ambiguity recruited a common "fronto-parietal-striatal" network including regions within the dorsolateral prefrontal cortex, intraparietal sulcus, and dorsal striatum. Activation was greatest across these regions and additional anterior and superior prefrontal regions for the quadratic function which most heavily weighs trials with partial ambiguity. These results suggest that the neural regions involved...Continue Reading

Citations

Apr 4, 2013·Neuroscience and Biobehavioral Reviews·Carol A Seger, Erik J Peterson
Dec 8, 2015·Frontiers in Behavioral Neuroscience·Helen PushkarskayaIfat Levy
Feb 24, 2015·Frontiers in Psychology·Yusuke TanakaHidehiko Takahashi
Aug 6, 2016·Bulletin of Experimental Biology and Medicine·A A FyodorovL I Kozlova
Feb 23, 2020·Drug and Alcohol Dependence·Ranjita PoudelMatthew T Sutherland
Jun 24, 2021·Social Cognitive and Affective Neuroscience·Shawn A RhoadsAbigail A Marsh

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