PMID: 5917775Sep 16, 1966

Coding properties of 7-methylguanine

Science
R C Wilhelm, D B Ludlum

Abstract

The abnormal base, 7-methylguanine, has been introduced into copolymers of uridylic and guanylic acids by methylation under controlled conditions. The resulting methylated copolymers have a markedly decreased template activity for polypeptide synthesis in vitro due to steric effects of the 7-methyl groups. Contrary to expectation, these polymers do not permit incorporation of amino acids whose codons contain the bases uracil and adenine.

Citations

Apr 23, 1979·Archives of Toxicology·A S WrightM F Wooder
Jan 1, 1969·Acta neurochirurgica·L Perria, G L Viale
Sep 24, 1968·Biochimica Et Biophysica Acta·R C Shank
Sep 17, 1969·Biochimica Et Biophysica Acta·B Hacker, L R Mandel
Mar 1, 1976·Chemico-biological Interactions·A E Pegg, A Jackson
Jul 1, 1967·Proceedings of the National Academy of Sciences of the United States of America·J D Axtell, R A Brink
Apr 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·B SingerJ T Kuśmierek
Jul 1, 1977·Journal of Toxicology and Environmental Health·B Singer
Aug 1, 1978·Photochemistry and Photobiology·R W HartF B Daniel
Sep 1, 1982·Mutation Research·T Gichner, J Velemínský
Jul 16, 1970·Biochimica Et Biophysica Acta·D B Ludlum
Mar 1, 1975·Toxicology and Applied Pharmacology·R C Shank
Sep 15, 1970·Biochemistry·B Singer, H Fraenkel-Conrat
Jan 1, 1971·Zeitschrift Für Krebsforschung Und Klinische Onkologie. Cancer Research and Clinical Oncology·W HennigF W Krüger

Related Concepts

Chromatography
Guanine
Guanine Nucleotides
Hydrogen-Ion Concentration
Clastogens
Polymers
Ultracentrifugation
Uracil Nucleotides

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