PMID: 2508660Jan 1, 1989Paper

Codon 61 mutations in the c-Harvey-ras gene in mouse skin tumors induced by 7,12-dimethylbenz[a]anthracene plus okadaic acid class tumor promoters

Molecular Carcinogenesis
H FujikiI B Weinstein

Abstract

Three okadaic acid class tumor promoters, okadaic acid, dinophysistoxin-1, and calyculin A, have potent tumor-promoting activity in two-stage carcinogenesis experiments on mouse skin. DNA isolated from tumors induced by 7,12-dimethylbenz[a]anthracene (DMBA) and each of these tumor promoters revealed the same mutation at the second nucleotide of codon 61 (CAA----CTA) in the c-Ha-ras gene, determined by the polymerase chain reaction procedure and DNA sequencing. Three potent 12-O-tetradecanoylphorbol-13-acetate (TPA)-type tumor promoters, TPA, teleocidin, and aplysiatoxin, showed the same effects. These results provide strong evidence that this mutation in the c-Ha-ras gene is due to a direct effect of DMBA rather than a selective effect of specific tumor promoters.

References

Aug 1, 1988·Pflügers Archiv : European journal of physiology·J HeschelerW Trautwein
Jan 1, 1987·Advances in Cancer Research·H Fujiki, T Sugimura
Mar 31, 1989·Biochemical and Biophysical Research Communications·T SassaH Fujiki
Mar 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M SuganumaT Sugimura
Oct 1, 1988·Japanese Journal of Cancer Research : Gann·H FujikiT Yasumoto

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Citations

Jan 1, 1992·Journal of Cancer Research and Clinical Oncology·R Nishiwaki-MatsushimaH Fujiki
Jan 1, 1996·Digestive Diseases and Sciences·T SutterP R Holt
Jan 27, 2007·Archives of Dermatological Research·Catherine A KraftRichard L Eckert
Jan 1, 1991·Comparative Immunology, Microbiology and Infectious Diseases·L Z Xu, D Larzul
Apr 23, 2013·Nature Medicine·Katherine L JamesonPaul A Khavari
Mar 4, 2000·Environmental Health Perspectives·B C HitzfeldD R Dietrich
Jun 1, 1991·Environmental Health Perspectives·H FujikiT Sugimura
Feb 1, 1997·Toxicon : Official Journal of the International Society on Toxinology·P CiminielloT Yasumoto
Jun 13, 2013·Journal of Cancer Research and Clinical Oncology·Hirota FujikiMasami Suganuma
Oct 13, 2007·Mutation Research·Dhrubajyoti ChakravartiEleanor G Rogan
Jan 24, 2014·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Rehab F KasemMona M AbdelMohsen
Jan 1, 1990·Chemico-biological Interactions·M R Osborne
Dec 12, 2012·The Journal of General Virology·Daniele ViarisioMassimo Tommasino
Apr 8, 2015·Regulatory Toxicology and Pharmacology : RTP·Michael SchwarzManigé Fartasch
Dec 2, 2014·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·Zorica SvirčevJussi Meriluoto
Jan 31, 2017·The Journal of Investigative Dermatology·Hiroyuki YamamotoZigang Dong
Jun 2, 2000·Gastroenterology·N ArberZ Halpern
Feb 11, 2000·Annals of the New York Academy of Sciences·T K Yun
Nov 14, 1997·Bioorganic & Medicinal Chemistry·J E SheppeckA R Chamberlin
Mar 1, 1990·Trends in Biochemical Sciences·P CohenY Tsukitani
Jan 1, 2007·CSH Protocols·Renata B FillerMichael Girardi

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