Codon Bias as a Means to Fine-Tune Gene Expression

Molecular Cell
Tessa E F QuaxJohn van der Oost


The redundancy of the genetic code implies that most amino acids are encoded by multiple synonymous codons. In all domains of life, a biased frequency of synonymous codons is observed at the genome level, in functionally related genes (e.g., in operons), and within single genes. Other codon bias variants include biased codon pairs and codon co-occurrence. Although translation initiation is the key step in protein synthesis, it is generally accepted that codon bias contributes to translation efficiency by tuning the elongation rate of the process. Moreover, codon bias plays an important role in controlling a multitude of cellular processes, ranging from differential protein production to protein folding. Here we review currently known types of codon bias and how they may influence translation. We discuss how understanding the principles of codon bias and translation can contribute to improved protein production and developments in synthetic biology.


May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·G A Gutman, G W Hatfield
Jan 1, 1986·Journal of Molecular Evolution·P M Sharp, W H Li
Aug 1, 1966·Journal of Molecular Biology·D SöllH G Khorana
Aug 1, 1966·Journal of Molecular Biology·F H Crick
Nov 25, 1982·Nucleic Acids Research·M Gouy, C Gautier
Jan 11, 1980·Nucleic Acids Research·R GranthamA Pavé
Mar 3, 2004·Proceedings of the National Academy of Sciences of the United States of America·Swaine L ChenHarley H McAdams
Jul 13, 2004·Trends in Biotechnology·Claes GustafssonJeremy Minshull
Sep 28, 2004·Nucleic Acids Research·Mario dos ReisLorenz Wernisch
Jan 29, 2005·EMBO Reports·Kimberly A DittmarTao Pan
Aug 17, 2005·PLoS Computational Biology·Johan Elf, Måns Ehrenberg
Feb 4, 2006·Molecular Cell·Kirill B GromadskiMarina V Rodnina
Feb 14, 2006·Nucleic Acids Research·J Ross BuchanIan Stansfield
Dec 23, 2006·Science·Chava Kimchi-SarfatyMichael M Gottesman
Dec 26, 2006·Journal of Molecular Biology·Paul F AgrisWilliam D Graham
Dec 30, 2006·PLoS Genetics·Kimberly A DittmarTao Pan
Dec 18, 2007·Molecular Cell·Ulrike BegleyThomas J Begley
Jun 28, 2008·Science·J Robert ColemanSteffen Mueller
Oct 10, 2008·BMC Genomics·Age TatsMaido Remm
Nov 6, 2008·Annual Review of Genetics·Ruth Hershberg, Dmitri A Petrov
Nov 11, 2008·Trends in Biochemical Sciences·Anton A Komar
Feb 10, 2009·Nature Structural & Molecular Biology·Gong ZhangZoya Ignatova
Apr 8, 2009·Molecular Biology and Evolution·Tong ZhouClaus O Wilke
Apr 11, 2009·Science·Grzegorz KudlaJoshua B Plotkin
Sep 18, 2009·PloS One·Mark WelchClaes Gustafsson
May 28, 2010·Protein Science : a Publication of the Protein Society·Barbara MaertensFrank Schäfer
Jun 10, 2010·Nucleic Acids Research·Rhodri Saunders, Charlotte M Deane
Oct 25, 2011·Nature Structural & Molecular Biology·Prashant K Khade, Simpson Joseph
Nov 3, 2011·RNA·Michael Stadler, Andrew Fire
Mar 1, 2012·Molecular Systems Biology·Milana Frenkel-MorgensternLars Juhl Jensen
Mar 20, 2012·Protein Expression and Purification·Claes GustafssonMark Welch
Apr 3, 2012·Cell·Eva Maria NovoaLluís Ribas de Pouplana
Apr 6, 2012·PLoS Genetics·Wenfeng QianJianzhi Zhang
Jun 19, 2012·Journal of Molecular Biology·Paige S SpencerJosé M Barral
Feb 23, 2013·Proceedings of the National Academy of Sciences of the United States of America·Christopher J WoolstenhulmeAllen R Buskirk
Apr 5, 2013·PLoS Biology·Catherine A Charneski, Laurence D Hurst

❮ Previous
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Feb 10, 2016·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Diego Luis GonzalezRodolfo Rosa
Feb 24, 2016·Life·Tamara Fernández-CaleroMónica Marín
Dec 10, 2015·Trends in Microbiology·Miguel Angel MartínezMaria Nevot
Jan 16, 2016·Wiley Interdisciplinary Reviews. RNA·Carolin Vogt, Jens Bohne
Sep 9, 2015·Journal of Molecular Biology·M J LajoieG M Church
Dec 15, 2015·Cell Reports·Guang-Zhong WangGenevieve Konopka
Oct 2, 2015·Journal of Theoretical Biology·Elena FimmelLutz Strüngmann
Sep 29, 2015·Nature Reviews. Microbiology·Jiqiang LingDieter Söll
Apr 16, 2016·Applied Microbiology and Biotechnology·Paolo SaccardoNeus Ferrer-Miralles
Jul 19, 2016·DNA Research : an International Journal for Rapid Publication of Reports on Genes and Genomes·Siddhartha Sankar SatapathySuvendra Kumar Ray
Jul 28, 2016·Current Opinion in Structural Biology·Annabel Ha ParretRob Meijers
Jul 28, 2016·Nucleic Acids Research·Henri Grosjean, Eric Westhof
Aug 20, 2016·Science·Nili OstrovGeorge M Church
Sep 8, 2016·Proceedings of the National Academy of Sciences of the United States of America·Michael G NapolitanoGeorge M Church
Sep 30, 2016·PloS One·Andrew M WatersJames L Hartley
Oct 12, 2016·Human Genetics·Jung-Ho ParkMasayori Inouye
Nov 4, 2016·Nature·Kaihang WangJason W Chin
Nov 12, 2016·Nature Communications·Yok Hian ChionhPeter C Dedon
Feb 6, 2017·Clinical Genetics·O BonczekO Šerý
Mar 12, 2017·Biomolecules·Richard J Maraia, Aneeshkumar G Arimbasseri
May 27, 2017·Genome Biology·Gleb KuznetsovGeorge M Church
Mar 18, 2017·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Andrew R Bassett
Jul 1, 2017·PloS One·Yizhou LiuJames H Prestegard
Oct 7, 2017·Current Genetics·James KuoPamela A Silver
Mar 7, 2018·Proceedings of the National Academy of Sciences of the United States of America·Amanda K TilotSimon E Fisher
Mar 2, 2018·International Journal of Molecular Sciences·Mira ParkJungeun Lee
Jan 3, 2018·The Journal of Pathology·Amal M El-Naggar, Poul H Sorensen
Apr 25, 2018·Genome Biology and Evolution·Adi YannaiRuth Hershberg
Jan 9, 2018·Genomics & Informatics·Eu-Hyun Im, Sun Shim Choi
Apr 15, 2017·Biochemical Society Transactions·Alicia A Bicknell, Emiliano P Ricci
Oct 12, 2017·Nature Reviews. Molecular Cell Biology·Gavin Hanson, Jeff Coller
Nov 7, 2017·Nature Structural & Molecular Biology·Sarah Azoubel LimaAmy E Pasquinelli
Oct 19, 2017·Molecular Biology and Evolution·Irepan Salvador-MartínezIsaac Salazar-Ciudad
May 16, 2018·Nature Reviews. Molecular Cell Biology·Anthony P Schuller, Rachel Green

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