Codon populations in single-stranded whole human genome DNA Are fractal and fine-tuned by the Golden Ratio 1.618

Interdisciplinary Sciences, Computational Life Sciences
Jean-Claude Perez

Abstract

This new bioinformatics research bridges Genomics and Mathematics. We propose a universal "Fractal Genome Code Law": The frequency of each of the 64 codons across the entire human genome is controlled by the codon's position in the Universal Genetic Code table. We analyze the frequency of distribution of the 64 codons (codon usage) within single-stranded DNA sequences. Concatenating 24 Human chromosomes, we show that the entire human genome employs the well known universal genetic code table as a macro structural model. The position of each codon within this table precisely dictates its population. So the Universal Genetic Code Table not only maps codons to amino acids, but serves as a global checksum matrix. Frequencies of the 64 codons in the whole human genome scale are a self-similar fractal expansion of the universal genetic code. The original genetic code kernel governs not only the micro scale but the macro scale as well. Particularly, the 6 folding steps of codon populations modeled by the binary divisions of the "Dragon fractal paper folding curve" show evidence of 2 attractors. The numerical relationship between the attractors is derived from the Golden Ratio. We demonstrate that: (i) The whole Human Genome Structure ...Continue Reading

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Citations

Aug 12, 2014·BioMed Research International·Hengwu LiKeith A Crandall
Nov 3, 2015·Journal of Biomolecular Structure & Dynamics·Marija RosandićVladimir Paar
Jul 17, 2018·PloS One·Yu Liu, David J T Sumpter

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