Codon recognition by enzymatically mischarged valine transfer ribonucleic acid

Science
D GrunbergerK B Jacobson

Abstract

Direct evidence for the adaptor hypothesis has been obtained by examining the codon recognition of a purified Escherichia coli valine transfer ribonucleic acid which was enzymatically mischarged with phenylalanine labeled with carbn-14 by reaction with purified phenylalanyl-transfer ribonucleic acid synthetase from Neurospora crassa. The mischarged transfer ribonucleic acid recognized the valine codons but failed to recognize the phenylalanine codon when tested in trinucleotide-directed ribosomal binding assay.

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Citations

Aug 1, 1992·Journal of Biomolecular Structure & Dynamics·N J Combates, S A Winkle

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