Codonopsis lanceolata Water Extract Increases Hepatic Insulin Sensitivity in Rats with Experimentally-Induced Type 2 Diabetes

Nutrients
Seong-Yeop JeongSunmin Park

Abstract

We examined the mechanisms and efficacy of Codonopsis lanceolata water extract (CLW) for treating type 2 diabetic (T2DM) symptoms. Partial pancreatectomized (Px) rats, a non-obese T2DM model, were provided high fat diets containing cellulose (control), 0.3% (CLW-L) or 1% CLW (CLW-H) for eight weeks. The positive control group was provided with rosiglitazone (20 mg/kg bw/day). The control group had lower epididymal fat masses than the CLW and the positive control groups, possibly due to urinary glucose loss, although CPT-1 and SIRT-1 expression was higher in the CLW group. CLW-H significantly reduced serum glucose levels and urinary glucose loss compared to the untreated control. The improvement of glucose utilization was associated with a higher fat mass in the CLW-H and positive control groups. Glucose-stimulated insulin secretion was higher in the untreated control than other groups and CLW tightly regulated insulin secretion as much as the positive control, and it was much tighter than the untreated control. Glucose infusion rates were higher during the hyperinsulinemic euglycemic clamp in the CLW and positive controls than the untreated control, and liver glucose outputs were lower during basal and hyperinsulinemic conditio...Continue Reading

References

Aug 8, 2001·The Journal of Clinical Investigation·J K KimG I Shulman
Nov 6, 2002·The Journal of Biological Chemistry·Yong Hee LeeMorris F White
Apr 10, 2007·Journal of Ethnopharmacology·Yong Gyu LeeJae Youl Cho
May 16, 2009·Expert Opinion on Therapeutic Patents·Francisco J Alcaín, José M Villalba
Jul 29, 2010·Journal of Cellular Biochemistry·Eun-Ha Joh, Dong-Hyun Kim
Oct 3, 2012·The Journal of Nutritional Biochemistry·Dae Young KwonSunmin Park
Oct 20, 2012·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Il-Hoon JungDong-Hyun Kim
Jan 26, 2013·Biochemical and Biophysical Research Communications·Yeon-Hui JeongHee-Sun Kim
Apr 5, 2013·Annals of the New York Academy of Sciences·Ronald C W Ma, Juliana C N Chan
Jul 3, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Hye-Kyung ChoiSe-Young Choung
Mar 1, 2015·Regulatory Toxicology and Pharmacology : RTP·Jong Seok LeeOk-Hwan Lee
Feb 26, 2016·Diabetes Care·Arun NandithaPaul Z Zimmet
Mar 5, 2016·Phytotherapy Research : PTR·Muhammad Jahangir HossenJae Youl Cho
Jun 18, 2016·Evidence-based Complementary and Alternative Medicine : ECAM·Jin Bae WeonChoong Je Ma
Sep 13, 2016·Diabetes, Obesity & Metabolism·M F BreretonF M Ashcroft
Jan 7, 2017·Journal of Cellular Biochemistry·Govindaraj JayanthySorimuthu Pillai Subramanian
Mar 10, 2017·Expert Opinion on Biological Therapy·André J Scheen

❮ Previous
Next ❯

Methods Mentioned

BETA
pancreatectomy
Reverse Transcription
PCR
protein
electrophoresis

Software Mentioned

SAS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.