CodY Regulates the Activity of the Virulence Quorum Sensor PlcR by Controlling the Import of the Signaling Peptide PapR in Bacillus thuringiensis

Frontiers in Microbiology
Leyla SlamtiDidier Lereclus

Abstract

In Gram-positive bacteria, cell-cell communication mainly relies on cytoplasmic sensors of the RNPP family. Activity of these regulators depends on their binding to secreted signaling peptides that are imported into the cell. These quorum sensing regulators control important biological functions in bacteria of the Bacillus cereus group, such as virulence and necrotrophism. The RNPP quorum sensor PlcR, in complex with its cognate signaling peptide PapR, is the main regulator of virulence in B. cereus and Bacillus thuringiensis (Bt). Recent reports have shown that the global stationary phase regulator CodY, involved in adaptation to nutritional limitation, is required for the expression of virulence genes belonging to the PlcR regulon. However, the mechanism underlying this regulation was not described. Using genetics and proteomics approaches, we showed that CodY regulates the expression of the virulence genes through the import of PapR. We report that CodY positively controls the production of the proteins that compose the oligopeptide permease OppABCDF, and of several other Opp-like proteins. It was previously shown that the pore components of this oligopeptide permease, OppBCDF, were required for the import of PapR. However, ...Continue Reading

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Citations

Jul 28, 2016·Frontiers in Microbiology·Racha MajedMichel Gohar
Nov 4, 2016·Frontiers in Microbiology·Diletta MazzantiniEmilia Ghelardi
Oct 3, 2017·Environmental Microbiology·Fernanda FazionDidier Lereclus
Sep 12, 2020·Organic & Biomolecular Chemistry·Dominic N McBrayerYftah Tal-Gan
Mar 30, 2020·Applied and Environmental Microbiology·Justyna Malgorzata DrewnowskaIzabela Swiecicka
Aug 4, 2019·Research in Microbiology·Leyla Slamti, Didier Lereclus
Feb 3, 2021·Toxins·Richard DietrichPer Einar Granum
May 22, 2019·Microbiology Spectrum·Monika Ehling-SchulzTheresa M Koehler

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Datasets Mentioned

BETA
PXD003311

Methods Mentioned

BETA
PCR
lecithinase

Software Mentioned

PSORTb

Related Concepts

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