Coefficient of Variation of Lifespan Across the Tree of Life: Is It a Signature of Programmed Aging?

Biochemistry. Biokhimii︠a︡
G A ShilovskyA V Markov

Abstract

Measurements of variation are of great importance for studying the stability of pathological phenomena and processes. For the biology of aging, it is very important not only to determine average mortality, but also to study its stability in time and the size of fluctuations that are indicated by the variation coefficient of lifespan (CVLS). It is believed that a relatively small (~20%) value of CVLSin humans, comparable to the coefficients of variation of other events programmed in ontogenesis (for example, menarche and menopause), indicates a relatively rigid determinism (N. S. Gavrilova et al. (2012) Biochemistry (Moscow), 77, 754-760). To assess the prevalence of this phenomenon, we studied the magnitude of CVLS, as well as the coefficients of skewness and kurtosis in diverse representatives of the animal kingdom using data provided by the Institute for Demographic Research (O. R. Jones et al. (2014) Nature, 505, 169-173). We found that, unlike humans and laboratory animals, in most examined species the values of CVLSare rather high, indicating heterogeneity of the lifespan in the cohorts studied. This is probably due to the large influence of background mortality, as well as the non-monotonicity of total mortality in the wi...Continue Reading

References

Sep 1, 1966·Journal of Theoretical Biology·W D Hamilton
Aug 1, 1996·Medical Hypotheses·N J Nusbaum
Oct 23, 1997·Science·C E Finch, R E Tanzi
May 23, 1998·Science·J W VaupelJ W Curtsinger
Nov 23, 2000·Nature·L Guarente, C Kenyon
Jul 12, 2003·Experimental Gerontology·Justin D CongdonDonald W Tinkle
Jan 22, 2005·Annual Review of Medicine·Jan Vijg, Yousin Suh
Nov 24, 2005·Nature Reviews. Genetics·Valter D LongoVladimir P Skulachev
Dec 13, 2005·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Rochelle Buffenstein
Nov 3, 2007·Journal of Cellular Biochemistry·Mikhail V Blagosklonny
Dec 1, 1947·The Quarterly Review of Biology·E S DEEVEY
May 19, 2010·Proceedings of the National Academy of Sciences of the United States of America·Robert E Ricklefs
Dec 1, 2010·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Thomas B L Kirkwood
Jul 24, 2012·Biochemistry. Biokhimii︠a︡·A V Markov
May 11, 2013·American Journal of Epidemiology·Jason J LiuImmaculata De Vivo
Jul 16, 2013·Biochemistry. Biokhimii︠a︡·G A ShilovskyS I Shram
Jul 19, 2013·Biogerontology·Arnold MitnitskiKenneth Rockwood
Nov 16, 2013·Biochemistry. Biokhimii︠a︡·A V Khalyavkin
Dec 10, 2013·Nature·Owen R JonesJames W Vaupel
Dec 19, 2014·Biochemistry. Biokhimii︠a︡·M V Skulachev, V P Skulachev
Feb 14, 2015·Aging Cell·Alexey A FushanVadim N Gladyshev
Nov 30, 2015·Biochemistry. Biokhimii︠a︡·V V AshapkinB F Vanyushin
Dec 8, 2015·Biochemistry. Biokhimii︠a︡·G A ShilovskyV P Skulachev
Jan 28, 2016·Nature·Nicholas StroustrupWalter Fontana
May 4, 2016·Proceedings of the National Academy of Sciences of the United States of America·Daniel A WarnerFredric J Janzen
Jan 18, 2017·Journal of Theoretical Biology·Andrei E TarkhovPeter O Fedichev
Mar 6, 2017·Biochemistry. Biokhimii︠a︡·G A ShilovskyV P Skulachev
Jun 29, 2017·Nature·Bryan G Hughes, Siegfried Hekimi
Jul 8, 2017·Journal of Molecular Biology·R Stegeman, V M Weake

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.