PMID: 6111675Apr 11, 1981Paper

Coeliac disease: a graft-versus-host-like reaction localised to the small bowel wall?

Lancet
G H Neild

Abstract

In coeliac disease, gluten, or one of its fractions, combines with a gut-wall macrophage or lymphocyte to form a lymphoid cell which is recognised by the host as foreign. It is proposed that this cell, rather than being eliminated as the target of a cell-mediated attack by the host, becomes autonomous and initiates a graft-versus-host (GvH)-like reaction. The reaction is largely confined to the gut wall and its associated lymphoid tissue. The severe cachexy and the peripheral lymph-node and splenic atrophy may be explained as features of chronic GvH disease. or a "runting" syndrome. Untreated coeliac disease may lead to lymphomatous transformation indistinguishable from the lymphoma of experimental chronic GvH disease

References

Nov 15, 1975·Lancet·B B Scott, M S Losowsky
Mar 6, 1976·Lancet·J J KeuningJ J va Rood
Nov 1, 1976·Gut·B B Scott, M S Losowsky
Apr 1, 1966·Gut·C F McCarthyA E Read
May 1, 1980·The Journal of Investigative Dermatology·G StinglE M Shevach

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