Coeliac Disease and Mast Cells

International Journal of Molecular Sciences
Barbara FrossiAntonino Calabrò

Abstract

Over the last decades, there has been an impressive progress in our understanding of coeliac disease pathogenesis and it has become clear that the disorder is the final result of complex interactions of environmental, genetic, and immunological factors. Coeliac disease is now considered a prototype of T-cell-mediated disease characterized by loss of tolerance to dietary gluten and the targeted killing of enterocytes by T-cell receptor αβ intraepithelial lymphocytes. Accumulating evidence, however, indicates that the induction of a gluten-specific T helper-1 response must be preceded by the activation of the innate immune system. Mast cells are key players of the innate immune response and contribute to the pathogenesis of a multitude of diseases. Here, we review the results of studies aimed at investigating the role of mast cells in the pathogenesis of coeliac disease, showing that these cells increase in number during the progression of the disease and contribute to define a pro-inflammatory microenvironment.

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Citations

Jan 17, 2020·International Journal of Molecular Sciences·Gilda Varricchi, Gianni Marone
Apr 1, 2020·F1000Research·Hwan Soo KimToshiaki Kawakami
Sep 24, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·José Antonio UrangaRaquel Abalo
Mar 10, 2021·Clinical and Experimental Medicine·Simone MarcellaStefania Loffredo
Apr 4, 2021·Animals : an Open Access Journal From MDPI·Giorgia Della Rocca, Davide Gamba
Oct 8, 2021·Scandinavian Journal of Gastroenterology·Marie StruffertAnjona Schmidt-Choudhury

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