Coeliac disease in children with type 1 diabetes

The Lancet Child & Adolescent Health
Kalle KurppaDaniel Agardh

Abstract

Coeliac disease and type 1 diabetes are the most common paediatric autoimmune disorders. Both conditions have increasing incidence and can often coexist in a patient. The diseases share many genetic and immunological features, but diagnostic and treatment approaches vary substantially worldwide. Because of the often subtle presentation of coeliac disease in children with type 1 diabetes, many are diagnosed only upon screening for coeliac disease. In this Review, we summarise approaches to diagnosis and treatment of children with type 1 diabetes and coeliac disease, with a specific emphasis on those with a double diagnosis. In particular, we examine the pros and cons of screening for coeliac disease and assess the challenges of dietary treatment in children with coexisting type 1 diabetes, which can already be a burden. Furthermore, we present the latest research on the shared genetic and pathogenic mechanisms and introduce some future perspectives.

Citations

Nov 20, 2018·Briefings in Bioinformatics·Eugenio Del PretePietro Liò
Jun 21, 2019·Journal of Diabetes·Jian-Min LiuUNKNOWN Chinese Society of Osteoporosis and Bone Mineral Research, the Chinese Society of Endocrinology, Chinese Diabetes Society, C
Dec 18, 2019·Journal of Pediatric Endocrinology & Metabolism : JPEM·Suna Selbuz, Ayşe Derya Buluş
Nov 5, 2019·The Journal of Clinical Endocrinology and Metabolism·Eitan Halper-StrombergViral N Shah
Jun 20, 2018·Acta Paediatrica·Laura Kivelä, Kalle Kurppa
Aug 14, 2019·Critical Reviews in Food Science and Nutrition·Beatriz Cabanillas
Aug 25, 2020·Journal of Pediatric Gastroenterology and Nutrition·German TapiaKetil Størdal
Oct 30, 2020·Acta Paediatrica·Hildegard Jasser-NitscheReinhard W Holl
Dec 12, 2020·Journal of Pediatric Gastroenterology and Nutrition·Petra RiznikJernej Dolinsek
Nov 13, 2020·The American Journal of Gastroenterology·German TapiaKetil Størdal
Apr 6, 2021·Annals of Saudi Medicine·Mohammed Zaid AljulifiAbdulwahed Abdulaziz Alotay
May 14, 2021·The American Journal of Gastroenterology·German TapiaKetil Størdal

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