Coenzyme Q is irreplaceable by demethoxy-coenzyme Q in plasma membrane of Caenorhabditis elegans

FEBS Letters
A ArroyoPlácido Navas

Abstract

A procedure was developed to isolate fractions enriched in plasma membrane from Caenorhabditis elegans. Coenzyme Q9 (Q9) was found in plasma membrane isolated from either wild-type or long-lived qm30 and qm51 clk-1 mutant strains of Caenorhabditis elegans, along with dietary coenzyme Q8 (Q8) and the biosynthetic intermediate demethoxy-Q9 (DMQ9). NADH was able to reduce both Q8 and Q9, but not DMQ9. Our results indicate that DMQ9 cannot achieve the same redox role of Q9 in plasma membrane, suggesting that proportion of all these Q isoforms in plasma membrane must be an important factor in establishing the clk-1 mutant phenotype.

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Citations

Jul 13, 2013·Human Molecular Genetics·Ying Wang, Siegfried Hekimi
Nov 30, 2012·Critical Reviews in Biochemistry and Molecular Biology·Ying Wang, Siegfried Hekimi
Jul 13, 2011·Mechanisms of Ageing and Development·Yu-Ying YangPhil G Morgan
Mar 3, 2010·Mechanisms of Ageing and Development·Guillermo López-LluchPlácido Navas
May 12, 2009·Mechanisms of Ageing and Development·Yu-Ying YangPhil G Morgan
Nov 15, 2008·Mechanisms of Ageing and Development·Claudio AsencioJuan Carlos Rodríguez-Aguilera
May 8, 2007·Mitochondrion·Plácido NavasRafael de Cabo
Mar 22, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Alfonso Varela-LópezJosé L Quiles
Aug 8, 2006·Experimental Gerontology·Zaruhi StepanyanSiegfried Hekimi
Apr 9, 2014·Experimental Gerontology·Beverley M DancyPhilip G Morgan
Nov 30, 2018·EMBO Molecular Medicine·Agustín Hidalgo-GutiérrezLuis C López
Sep 22, 2019·Nutrients·M Elena Díaz-CasadoAlfonso Varela-López
Feb 8, 2021·Free Radical Biology & Medicine·José Manuel Villalba, Plácido Navas

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