Coenzyme Q10 combined with trimetazidine in the prevention of contrast-induced nephropathy in patients with coronary heart disease complicated with renal dysfunction undergoing elective cardiac catheterization: a randomized control study and in vivo study

European Journal of Medical Research
Fei ChenJie Zhang

Abstract

Contrast-induced nephropathy (CIN) is one of the common hospital-acquired acute renal failures. The purpose of this study was to investigate whether Coenzyme Q10 (CoQ10) and trimetazidine (TMZ) can prevent the occurrence of CIN after elective cardiac catheterization in patients with coronary artery disease complicated with renal dysfunction. Consecutive coronary artery disease patients with renal insufficiency scheduled for coronary angiography were enrolled in randomized, paralleled, double-blind, controlled trial. The development of CIN was occurrence at the 48 or 72 h after the procedure. The changes of serum creatinine (SCr), eGFR, and Cys-C within 72 h after the procedure were measured and compared. In vivo contrast medium (CM)-induced acute kidney injury (AKI) animal model was established, and CoQ10 plus TMZ was orally administrated to evaluate its renal protective effect. 150 patients with renal insufficiency were enrolled finally. CIN occurred in 21 (14.00%) of the 150 patients. 72 h after the procedure, the incidence of CIN was significantly lower in CoQ10 plus TMZ group compared with control group (6.67 vs. 21.3%, p = 0.01). No cardiac death occurred in this study. No side effects were observed after administration of...Continue Reading

References

Jan 14, 2005·The International Journal of Artificial Organs·H M Oudemans-van Straaten
Feb 4, 2010·Nature Reviews. Nephrology·Alexandra ChronopoulosClaudio Ronco
Oct 5, 2010·Cardiology Research and Practice·Sana ShoukatSajid H Dhakam
Mar 29, 2014·BioMed Research International·Antonella CaiazzaDomenico Russo
Jan 7, 2015·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Xuhe GongGuogan Wang
Apr 4, 2015·Journal of Clinical Biochemistry and Nutrition·Hiroko P IndoHideyuki J Majima
Feb 14, 2016·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Giuseppe AmbrosioPeter J Grant
Aug 18, 2016·European Heart Journal. Cardiovascular Pharmacotherapy·Cian P McCarthyDavid M Kerins

❮ Previous
Next ❯

Software Mentioned

SPSS

Related Concepts

Related Feeds