Coenzyme Q(10) enhances dermal elastin expression, inhibits IL-1α production and melanin synthesis in vitro

International Journal of Cosmetic Science
M ZhangR Zhao

Abstract

Coenzyme Q(10) (CoQ(10) ) is a well-known antioxidant and has been used in many skincare products for anti-ageing purpose. However, the molecular mechanisms of CoQ(10) function in skin cells are not fully understood. In this paper, we compared the effects of CoQ(10) on primary human dermal fibroblasts from three individuals, including adult. We demonstrated that CoQ(10) treatment promoted proliferation of fibroblasts, increased type IV collagen expression and reduced UVR-induced matrix metalloproteinases-1 (MMP-1) level in embryonic and adult cells. In addition, CoQ(10) treatment increased elastin gene expression in cultured fibroblasts and significantly decreased UVR-induced IL-1α production in HaCat cells. Taken together, CoQ(10) presented anti-ageing benefits against intrinsic ageing as well as photo damage. Interestingly, CoQ(10) was able to inhibit tyrosinase activity, resulting in reduced melanin content in B16 cells. Thus, CoQ(10) may have potential depigmentation effects for skincare.

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Citations

Nov 20, 2012·Matrix Biology : Journal of the International Society for Matrix Biology·Erin P Sproul, W Scott Argraves
Apr 26, 2019·Journal of Cosmetic Dermatology·Mavişe YükselGözde Ülfer
Mar 28, 2020·Nutrients·Changwei CaoChangrong Ge
Jun 21, 2014·International Journal of Molecular Medicine·Jina RyuTaek-Jeong Nam
May 27, 2020·International Journal of Cosmetic Science·K KennedyN Khaldi
Oct 12, 2018·International Journal of Molecular Sciences·David L VollmerEdwin D Lephart
Jun 30, 2016·Food Science and Biotechnology·Young-Hee Pyo, Yoo-Jeong Jin
Nov 16, 2020·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Yaser AlkhatibDagmar Fischer
Jan 23, 2021·Free Radical Biology & Medicine·Fabio MarcheggianiLuca Tiano
Jun 3, 2021·Antioxidants·Yoana Rabanal-RuizFrancisco Javier Alcain

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