Coenzyme Q10 fetal plasma levels

Fetal Diagnosis and Therapy
G NoiaS Mancuso

Abstract

This study aims at determining a cutoff value differentiating the fetal from the adult coenzyme Q10 (CoQ10) values and comparing substantial increases in CoQ10 plasma levels in fetuses with hypoxic hypoxia and nonimmune fetal hydrops. We have selected 61 pregnancies and determined the CoQ10 levels in fetal and maternal samples obtained by cordocentesis. Our study included a control group and pregnancies with intrauterine growth retardation, Rh isoimmunization, nonimmune fetal hydrops, and fetal malformations. To differentiate the fetal from the adult values we have set 0.3 mg/ml as the cutoff value. The CoQ10 were higher only in fetuses with hypoxic hypoxia and nonimmune hydrops. Normal fetal CoQ10 plasma levels are lower than 0.3 mg/ml.

Citations

Jul 29, 2006·BioFactors·Stefano R GiannubiloGian Paolo Littarru
May 28, 2011·Journal of Assisted Reproduction and Genetics·Yaakov BentovRobert F Casper
Dec 4, 2003·Free Radical Biology & Medicine·Enrique TeranAndres Calle
May 24, 2003·Clinica Chimica Acta; International Journal of Clinical Chemistry·Michael V MilesAmadeo J Pesce
May 31, 2002·Experimental Biology and Medicine·Giuseppina MilanoMichele Samaja
Dec 2, 2018·Frontiers in Physiology·Enrique TeranAndrés Calle

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