Coenzyme Q10 in acute influenza.

Influenza and Other Respiratory Viruses
Maureen ChaseMichael W Donnino

Abstract

The goal of this investigation was to determine if acute influenza infection is associated with depletion of CoQ10 compared to healthy controls and to determine any associations between CoQ10 levels and illness severity and inflammatory biomarkers. We analyzed serum CoQ10 concentrations of patients with acute influenza enrolled in a randomized clinical trial prior to study drug administration. Patients were enrolled at a single urban tertiary care center over 3 influenza seasons (December 27, 2013 to March 31, 2016). Wilcoxon rank sum test was used to compare CoQ10 levels between influenza patients and healthy controls. Correlations with inflammatory biomarkers and severity of illness were assessed using Spearman correlation coefficient. We analyzed CoQ10 levels from 50 patients with influenza and 29 controls. Overall, patients with acute influenza had lower levels of CoQ10 (.53 μg/mL, IQR .37-.75 vs .72, IQR .58-.90, P = .004). Significantly more patients in the influenza group had low CoQ10 levels (<.5 μg/mL) compared to controls (48% vs 7%, P < .001). Among influenza patients, there were significant but weak correlations between CoQ10 levels and IL-2 (r = -.30, P = .04), TNF-alpha (r = -.35, P = .01) and VEGF (r = .38, P = ....Continue Reading

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Citations

Jun 17, 2020·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Shabnam Salimi, John M Hamlyn
Dec 22, 2020·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Giovanni PaganoMarco Trifuoggi
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Clinical Trials Mentioned

NCT02056340

Software Mentioned

SAS

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